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Structural study of antisense dimers, modified adenosine-thymidine phosphorothioate

Title
Structural study of antisense dimers, modified adenosine-thymidine phosphorothioate
Authors
Jung, KEYang, MLee, KLim, HJung, JKoo, BJeong, LSSin, DHLee, CHCho, YHLim, Y
Ewha Authors
정낙신
Issue Date
2000
Journal Title
JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
ISSN
1017-7825JCR Link
Citation
vol. 10, no. 6, pp. 889 - 892
Keywords
antisensenucleotidedimerNMR
Publisher
KOREAN SOC APPLIED MICROBIOLOGY
Indexed
SCIE; SCOPUS; KCI WOS
Abstract
Antisense molecules are structurally simple linear oligomers of nucleotides. They can recognize a complementary sequence by base pairing, therefore, antisense drugs composed of 15-16 bases are potentially useful, unlike drugs such as protein agonists, antagonists, and inhibitors. Since antisense oligomers are classified as nucleotides, they are subject to attack by nucleases. In order to be antisense drugs resistant to degradation by nucleases, the structural modifications in the linkages, bases, and sugars to satisfy this requirement are considerable. We attempted in this study, to synthesize 16-mer antisenses with a modified linkage and adenosine. When studying on the three-dimensional structure of the oligomer, however, the existence of isomers may complicate the interpretation of the NMR data. Therefore, an attempt was made to eliminate the above problem, thus, two dimers were synthesized and their structural studies were carried out.
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약학대학 > 약학과 > Journal papers
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