View : 36 Download: 0
Structural study of antisense dimers, modified adenosine-thymidine phosphorothioate
- Structural study of antisense dimers, modified adenosine-thymidine phosphorothioate
- Jung, KE; Yang, M; Lee, K; Lim, H; Jung, J; Koo, B; Jeong, LS; Sin, DH; Lee, CH; Cho, YH; Lim, Y
- Ewha Authors
- Issue Date
- Journal Title
- JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
- vol. 10, no. 6, pp. 889 - 892
- antisense; nucleotide; dimer; NMR
- KOREAN SOC APPLIED MICROBIOLOGY
- SCIE; SCOPUS; KCI
- Antisense molecules are structurally simple linear oligomers of nucleotides. They can recognize a complementary sequence by base pairing, therefore, antisense drugs composed of 15-16 bases are potentially useful, unlike drugs such as protein agonists, antagonists, and inhibitors. Since antisense oligomers are classified as nucleotides, they are subject to attack by nucleases. In order to be antisense drugs resistant to degradation by nucleases, the structural modifications in the linkages, bases, and sugars to satisfy this requirement are considerable. We attempted in this study, to synthesize 16-mer antisenses with a modified linkage and adenosine. When studying on the three-dimensional structure of the oligomer, however, the existence of isomers may complicate the interpretation of the NMR data. Therefore, an attempt was made to eliminate the above problem, thus, two dimers were synthesized and their structural studies were carried out.
- Appears in Collections:
- 약학대학 > 약학과 > Journal papers
- Files in This Item:
There are no files associated with this item.
- RIS (EndNote)
- XLS (Excel)
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.