View : 28 Download: 0
Effect of exercise on the mitochondrial DNA content of peripheral blood in healthy women
- Effect of exercise on the mitochondrial DNA content of peripheral blood in healthy women
- Lim, S; Kim, SK; Park, KS; Kim, SY; Cho, BY; Yim, MJ; Lee, HK
- Ewha Authors
- SCOPUS Author ID
- Issue Date
- Journal Title
- EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
- vol. 82, no. 5-6, pp. 407 - 412
- mitochondrial DNA; maximal exercise capacity; exercise; competitive polymerase chain reaction; insulin resistance
- SCI; SCIE; SCOPUS
- Exercise decreases insulin resistance and increases maximal exercise capacity as estimated from maximal oxygen uptake ((V) over dotO(2max)). Recent reports have demonstrated that the mitochondrial DNA (mtDNA) content of blood is correlated with (V) over dotO(2max) in healthy subjects (mean age 31 years) and is inversely correlated with insulin resistance parameters, The aim of this study was to determine the effect of regular exercise on the mtDNA content in the peripheral blood of 16 healthy young women of mean age 24.8 (SD 6.2) years and 14 healthy older women of mean age 66.7 (SD 5.8) years. The exercise programme lasted for 10 weeks and consisted of three sessions a week, each of 1 h and aiming to attain 60%-80% of (V) over dotO(2max). The mtDNA content of peripheral blood was measured by competitive polymerase chain reaction. The (V) over dotO(2max) had significantly increased following the exercise programme [from 33.1 (SD 3.4) to 35.2 (SD 3.4) ml . kg(-1) . min(-1) in the young and from 34.3 (SD 5.3) to 30.3 (SD 7.3) ml . kg(-1) . min(-1) in the older women, both P < 0.05]. Exercise decreased systolic blood pressure, and concentrations of triglyceride, low density lipoprotein-cholesterol (LDL-C), glucose and insulin in the blood of the young and of total cholesterol, LDL-C and glucose in that of the older women. High density lipoprotein-cholesterol (HDL-C) in the young women was increased by exercise. The mtDNA content significantly increased following the exercise programme in both groups [from 27.1 (SD 17.9) to 52.7 (SD 44.6) amol . 5 ng(-1) genomic DNA in the young and from 15.3 (SD 10.2) to 32.1 (SD 30.0) amol . 5 ng(-1) genomic DNA in the older women, both P < 0.05]. There was a significant positive correlation between the change in mtDNA content and the change in (V) over dotO(2max) (r = 0.74 in the young and r = 0.71 in the older women, both P < 0.01). In conclusion, 10 weeks of moderate intensity, regular exercise increased the mtDNA content in peripheral blood and decreased insulin resistance parameters, This data suggests that increase in the mtDNA content may be associated with increased insulin sensitivity.
- Appears in Collections:
- 신산업융합대학 > 체육과학부 > Journal papers
- Files in This Item:
There are no files associated with this item.
- RIS (EndNote)
- XLS (Excel)
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.