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Effect of exercise on the mitochondrial DNA content of peripheral blood in healthy women

Title
Effect of exercise on the mitochondrial DNA content of peripheral blood in healthy women
Authors
Lim, SKim, SKPark, KSKim, SYCho, BYYim, MJLee, HK
Ewha Authors
임미자
SCOPUS Author ID
임미자scopus
Issue Date
2000
Journal Title
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
ISSN
1439-6319JCR Link
Citation
vol. 82, no. 5-6, pp. 407 - 412
Keywords
mitochondrial DNAmaximal exercise capacityexercisecompetitive polymerase chain reactioninsulin resistance
Publisher
SPRINGER-VERLAG
Indexed
SCI; SCIE; SCOPUS WOS
Abstract
Exercise decreases insulin resistance and increases maximal exercise capacity as estimated from maximal oxygen uptake ((V) over dotO(2max)). Recent reports have demonstrated that the mitochondrial DNA (mtDNA) content of blood is correlated with (V) over dotO(2max) in healthy subjects (mean age 31 years) and is inversely correlated with insulin resistance parameters, The aim of this study was to determine the effect of regular exercise on the mtDNA content in the peripheral blood of 16 healthy young women of mean age 24.8 (SD 6.2) years and 14 healthy older women of mean age 66.7 (SD 5.8) years. The exercise programme lasted for 10 weeks and consisted of three sessions a week, each of 1 h and aiming to attain 60%-80% of (V) over dotO(2max). The mtDNA content of peripheral blood was measured by competitive polymerase chain reaction. The (V) over dotO(2max) had significantly increased following the exercise programme [from 33.1 (SD 3.4) to 35.2 (SD 3.4) ml . kg(-1) . min(-1) in the young and from 34.3 (SD 5.3) to 30.3 (SD 7.3) ml . kg(-1) . min(-1) in the older women, both P < 0.05]. Exercise decreased systolic blood pressure, and concentrations of triglyceride, low density lipoprotein-cholesterol (LDL-C), glucose and insulin in the blood of the young and of total cholesterol, LDL-C and glucose in that of the older women. High density lipoprotein-cholesterol (HDL-C) in the young women was increased by exercise. The mtDNA content significantly increased following the exercise programme in both groups [from 27.1 (SD 17.9) to 52.7 (SD 44.6) amol . 5 ng(-1) genomic DNA in the young and from 15.3 (SD 10.2) to 32.1 (SD 30.0) amol . 5 ng(-1) genomic DNA in the older women, both P < 0.05]. There was a significant positive correlation between the change in mtDNA content and the change in (V) over dotO(2max) (r = 0.74 in the young and r = 0.71 in the older women, both P < 0.01). In conclusion, 10 weeks of moderate intensity, regular exercise increased the mtDNA content in peripheral blood and decreased insulin resistance parameters, This data suggests that increase in the mtDNA content may be associated with increased insulin sensitivity.
DOI
10.1007/s004210000238
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신산업융합대학 > 체육과학부 > Journal papers
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