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Studies on the antithrombotic and antiplatelet activities of NQ304, a newly synthesized naphthoquinone derivative

Title
Studies on the antithrombotic and antiplatelet activities of NQ304, a newly synthesized naphthoquinone derivative
Authors
Yuk, DYLee, HYRyu, CKHong, JTKang, WSYoo, HSYun, YP
Ewha Authors
유충규
SCOPUS Author ID
유충규scopus
Issue Date
2000
Journal Title
ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH
ISSN
0004-4172JCR Link
Citation
vol. 50, no. 3, pp. E254 - E259
Keywords
anticoagulationantiplatelet agentantithrombotic agent1,4-naphthoquinoneNQ304
Publisher
ECV-EDITIO CANTOR VERLAG MEDIZIN NATURWISSENSCHAFTEN
Indexed
SCOPUS WOS scopus
Abstract
The effect of NQ304 (2-chloro-3-(4-hexylphenyl)-amino-1,4-naphthoquinone) as a novel antithrombotic agent was investigated. NQ304 was found to inhibit platelet aggregation in human platelets in vitro and in rat ex vivo, and murine pulmonary thrombosis in vivo. NQ304 potently inhibited adenosine diphosphate (ADP), collagen, epinephrine and calcium ionophore-induced human platelet aggregation in vitro dose-dependently. In the ex vivo study, oral administration of NQ304 significantly inhibited platelet aggregation in rats. However, NQ304: was found not to affect the coagulation system, since it did not change the prothrombin time (PT), activated partial thromboplastin time (APTT) and thrombin time (TT), The agent prevented death due to pulmonary thrombosis by the platelet aggregates in mice in vivo. In the mouse tail bleeding time test, NQ304 showed a significant prolongation of the tail bleeding time in conscious mice. These results suggest that a principal antithrombotic effect of NQ304 may be due to the antiplatelet aggregation activity but not to anticoagulation activity.
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약학대학 > 약학과 > Journal papers
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