Acyl-CoA : cholesterol acyltransferase inhibitory activity of lignans isolated from Schizandra, Machilus and Magnolia species

Abstract

Fifteen lignans were isolated from the fruits of Schizandra chinensis, the leaves of Machilus thunbergii, and the flower buds of Magnolia denudata. They were identified as gomisins, schizandrin, wuweizisu, schizantherin, licarins, and machilin, which inhibited rat liver ACAT with IC50 values of 25 - 200 mu M. Gomisin N is the most potent inhibitor with IC50 value of 25 mu M in these lignans.