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Acyl-CoA : cholesterol acyltransferase inhibitory activity of lignans isolated from Schizandra, Machilus and Magnolia species
- Title
- Acyl-CoA : cholesterol acyltransferase inhibitory activity of lignans isolated from Schizandra, Machilus and Magnolia species
- Authors
- Kwon, BM; Jung, HJ; Lim, JH; Kim, YS; Kim, MK; Kim, YK; Bok, SH; Bae, KH; Lee, IR
- Ewha Authors
- 이인란
- SCOPUS Author ID
- 이인란
- Issue Date
- 1999
- Journal Title
- PLANTA MEDICA
- ISSN
- 0032-0943
- Citation
- PLANTA MEDICA vol. 65, no. 1, pp. 74 - 76
- Publisher
- GEORG THIEME VERLAG
- Indexed
- SCIE; SCOPUS
- Document Type
- Letter
- Abstract
- Fifteen lignans were isolated from the fruits of Schizandra chinensis, the leaves of Machilus thunbergii, and the flower buds of Magnolia denudata. They were identified as gomisins, schizandrin, wuweizisu, schizantherin, licarins, and machilin, which inhibited rat liver ACAT with IC50 values of 25 - 200 mu M. Gomisin N is the most potent inhibitor with IC50 value of 25 mu M in these lignans.
- DOI
- 10.1055/s-2006-960443
- Appears in Collections:
- 약학대학 > 약학과 > Journal papers
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