Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 유충규 | - |
dc.date.accessioned | 2016-08-27T02:08:17Z | - |
dc.date.available | 2016-08-27T02:08:17Z | - |
dc.date.issued | 1998 | - |
dc.identifier.issn | 0253-6269 | - |
dc.identifier.other | OAK-75 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/215265 | - |
dc.description.abstract | A series of 6-(N-arylamino)-7-methylthio-5,8-quinolined lone derivatives 4a-4l was newly synthesized for the evaluation of antifungal activity. 6-(N-Arylamino)-7-methylthio-5,8-quinolinediones were prepared by regioselective nucleophilic substitution of 6,7-dichloro-5,8-quinolinediones with arylamines in the presence of Ce3+, and Na2S/dimethylsulfate. The MIC values of 4a-4l were determined for antifungal susceptibility in vitro against Candida species by agar streak method. The derivatives 4a-4l had generally potent antifungal activities against all human pathogenic fungi. Especially they had the most potent activity against C, krusei at 12.5 similar to 0.8 mu g/ml. Compounds 4d, 4g, 4h, 4j and 4k had more potent antifungal activities than fluconazole. Compounds 4g and 4h completely inhibited the fungal growth at 0.8 similar to 6.3 mu g/ml against all Candida species, while fluconazole inhibited the growth at 25 mu g/ml. The compounds such as 4g and 4h containing an N-(4-bromo-2-methylphenyl)- or N-(4-bromo-3-methylphenyl)amino substituent exhibited the most potent antifungal activities. | - |
dc.language | English | - |
dc.publisher | PHARMACEUTICAL SOCIETY KOREA | - |
dc.subject | 6-(N-arylamino)-7-methylthio-5,8-quinolinedione antifungal activity | - |
dc.subject | MIC minimum | - |
dc.subject | inhibitory concentration | - |
dc.subject | Candida species | - |
dc.title | Synthesis and antifungal evaluation of 6-(N-Arylamino)-7-methylthio-5,8-quinolinediones | - |
dc.type | Article | - |
dc.relation.issue | 4 | - |
dc.relation.volume | 21 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.index | KCI | - |
dc.relation.startpage | 440 | - |
dc.relation.lastpage | 444 | - |
dc.relation.journaltitle | ARCHIVES OF PHARMACAL RESEARCH | - |
dc.identifier.doi | 10.1007/BF02974640 | - |
dc.identifier.wosid | WOS:000075325000014 | - |
dc.identifier.scopusid | 2-s2.0-0032129964 | - |
dc.author.google | Ryu, CK | - |
dc.author.google | Choi, JA | - |
dc.author.google | Kim, SH | - |
dc.contributor.scopusid | 유충규(15846918400) | - |
dc.date.modifydate | 20180104081001 | - |