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Binding of murine leukemia virus Gag polyproteins to KIF4, a microtubule-based motor protein

Title
Binding of murine leukemia virus Gag polyproteins to KIF4, a microtubule-based motor protein
Authors
Kim, WKTang, YOkada, YTorrey, TAChattopadhyay, SKPfleiderer, MFalkner, FGDorner, FChoi, WHirokawa, NMorse, HC
Ewha Authors
최원자
SCOPUS Author ID
최원자scopus
Issue Date
1998
Journal Title
JOURNAL OF VIROLOGY
ISSN
0022-538XJCR Link
Citation
vol. 72, no. 8, pp. 6898 - 6901
Publisher
AMER SOC MICROBIOLOGY
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
A cDNA clone encoding a cellular protein that interacts with murine leukemia virus (MuLV) Gag proteins was isolated from a T-cell lymphoma library. The sequence of the clone is identical to the C terminus of a cellular protein, KIF4, a microtubule-assoclated motor protein that belongs to the kinesin superfamily. KTF4-MuLV Gag associations have been detected in vitro and in vivo in mammalian cells. We suggest that KIF4 could be involved in Gag polyprotein translocation from the cytoplasm to the cell membrane.
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자연과학대학 > 생명과학전공 > Journal papers
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