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한국인 집단의 태반내 효소 다형현상에 대한 연구

Title
한국인 집단의 태반내 효소 다형현상에 대한 연구
Other Titles
(The) polymmorphism on placental enzymes in koran population
Authors
柳貞花
Issue Date
1987
Department/Major
대학원 생물학과
Keywords
한국인태반효소다형현상
Publisher
이화여자대학교 대학원
Degree
Master
Advisors
정용재
Abstract
한국인 집단의 유전적 변이를 태반내 효소의 다형현상에서 파악하기 위하여 esterase D (ESD ; E. C. 3. 1. 1. 1), alkaline Phosphatase (ALP ; E, C. 3. 1. 3. 1)와 acid phosphatase (ACP ; E. C. 3. 1. 3. 2)등 3종의 효소들을 서울에 거주하는 임산부들을 대상으로하여 starch gel. 전기영동법으로 분석한 결과는 다음과 같다. 1. ESD isozyme은 ESD^(1)과 ESD^(2)의 2개 대립인자가 발견되었으며 rare allele와 variant유형은 발견되지 않았다. 2. ESD 좌위의 대립인자 빈도는 ESD^(1)과 ESD^(2)가 각각 0.663과 0.337로 나타났다. 3. 사람의 태반에서 나타나는 ALP isozyme은 간·골격·신장의 ALP_(L)과 ALP_(I) 좌위와는 다른 PL 좌위로 지배됨이 발견되었다. 4. PL isozyme은 'PL^(1) , PL^(2), PL^(3)의 3개 대립인자로 결정되는 6개 공통 표현형과 1개체의 rare표현형 (PL 4 - 1)이 발견되었다. 5. PL 좌위의 대립인자 빈도는 PL^(1), PL^(2), PL^(3)와 PL^(rare)가 각각 0. 727, 0.081, 0. 191 그리고 0.001로써 나타났다. 6. 태반에서 나타나는 ACP isozyme은 적혈구의 ACP_(1)과는 서로 분리된 ACP_(2) ACP_(3) 좌위로 결정되며 본 실험에서는 ACP_(3) 좌위에서 5개체의 variant유형 (ACP_(3) 2 - 1)이 발견되었다.;Polymorphism of placental enzymes (ESD, ALP, ACP) was studied by means of starch-gel electrophoresis in unrelated placental donors living in Seoul, Korea. The results obtained were as follows: 1. As to ESD isozyme, there were two alleles, ESD^(1) and ESD^(2), in Korean population. No variant type was found. 2. The gene frequencies of ESD alleles were found to be: 0.663 for ESD^(1), 0.337 for ESD^(2). 3. The ALP pheonotypes in human placenta could be explained by the different locus (PL) with three alleles distinct from the ALP_(L) (in Liver, bone and kidney) and ALP_(I) (in intestine). 4. As to PL isozyme, there were three alleles, PL^(1), PL^(2), and PL^(3), in Korean population. One of the variants (PL 4-1) was found in the present study. 5. The gene frequencies of alleles were found to be: 0.727 for PL^(1), 0,081 for PL^(2), 0.191 for PL^(3), and 0.001 for PL^(rare). 6. The ACP phenotypes in placenta could be explained by the ACP_(2) and ACP_(3) locus distinct from the ACP_(1) (in erythrocyte). The five variants (ACP_(3) 2-1) at ACP_(3) locus were found in the present study. 7. The statistical analysis of these frequencies under Hardy-Weinberg equlibrium showed good agreement between the observed and the expected values.
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