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Chlorpropamide의 Cyclodextins와의 Inclusion Complex에 관한 연구

Title
Chlorpropamide의 Cyclodextins와의 Inclusion Complex에 관한 연구
Other Titles
INCLUSION COMPLEXATION OF CHLORPROPAMIDE WITH CYCLODEXTRINS IN AQUEOUS SOLUTION AND IN THE SOLID STATE
Authors
정경혜
Issue Date
1986
Department/Major
대학원 약학과
Keywords
ChlorpropamideCyclodextinsInclusion Complex
Publisher
이화여자대학교 대학원
Degree
Master
Advisors
具永順
Abstract
經口糖尿病治療樂으로 사용되는 難溶性藥物인 chlorpropamide와 α-cyclodextrin, β-cyclodextrin 및 tri-O-methyl-β-cyclodextrin을 각각 같은 mole比로 凍結乾燥法에 의해 solid complex를 調製하였으며 溶解度 測定, spectroscopy(UV, IR), differential scanning calorimetry 및 粉末 X-ray diffractometry에 의하여 검토한 결과, chlorpropamide가 세종류의 cycledextrin과 1:1의 inclusion complex를 형성함을 확인하였다. 그리고 각 inclusion complex의 溶出特性을 검토한 결과, chlorpropamide의 溶出이 현저하게 증가하였으며, intrinsic dissolution rate는 chlorpropamide에 비하여 chlorpropamide와 α-cyclode-xtrin의 inclusion complex에서 51배 증가하였고 chlorpropamide와 β- cyclodextrin의 inclusion complex는 12배로 증가하였다.;Inclusion complexations of α-cyclodextrin, β-cyclodextrin and tri-O-methyl-β-cyclodextrin with chlorpropamide in aqueous solution and in the solid state were studied by the solubility method, spectroscopy (UV, IR), differential scanning calorimetry and powder X-ray diffractometry, and all their molar ratios were found to be 1:1. The solid complexes of chlorpropamide with three kinds of cyclodextrins were prepared by a freeze-drying method, and their dissolution behaviors were examined. As a result, the release of chlorpropamide from the inclusion complexes was significantly improved. The intrinsic dissolution rate of chlorpropamide in cyclodextrin inclusion complexe was about 51 times ( α-cyclodextrin inclusion complex) and 12 times ( β-cyclodextrin inclusion complex) larger than that of intact chlorpropamide.
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