Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | 具永順 | - |
dc.contributor.author | 정경혜 | - |
dc.creator | 정경혜 | - |
dc.date.accessioned | 2016-08-26T03:08:23Z | - |
dc.date.available | 2016-08-26T03:08:23Z | - |
dc.date.issued | 1986 | - |
dc.identifier.other | OAK-000000014270 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/206673 | - |
dc.identifier.uri | http://dcollection.ewha.ac.kr/jsp/common/DcLoOrgPer.jsp?sItemId=000000014270 | - |
dc.description.abstract | 經口糖尿病治療樂으로 사용되는 難溶性藥物인 chlorpropamide와 α-cyclodextrin, β-cyclodextrin 및 tri-O-methyl-β-cyclodextrin을 각각 같은 mole比로 凍結乾燥法에 의해 solid complex를 調製하였으며 溶解度 測定, spectroscopy(UV, IR), differential scanning calorimetry 및 粉末 X-ray diffractometry에 의하여 검토한 결과, chlorpropamide가 세종류의 cycledextrin과 1:1의 inclusion complex를 형성함을 확인하였다. 그리고 각 inclusion complex의 溶出特性을 검토한 결과, chlorpropamide의 溶出이 현저하게 증가하였으며, intrinsic dissolution rate는 chlorpropamide에 비하여 chlorpropamide와 α-cyclode-xtrin의 inclusion complex에서 51배 증가하였고 chlorpropamide와 β- cyclodextrin의 inclusion complex는 12배로 증가하였다.;Inclusion complexations of α-cyclodextrin, β-cyclodextrin and tri-O-methyl-β-cyclodextrin with chlorpropamide in aqueous solution and in the solid state were studied by the solubility method, spectroscopy (UV, IR), differential scanning calorimetry and powder X-ray diffractometry, and all their molar ratios were found to be 1:1. The solid complexes of chlorpropamide with three kinds of cyclodextrins were prepared by a freeze-drying method, and their dissolution behaviors were examined. As a result, the release of chlorpropamide from the inclusion complexes was significantly improved. The intrinsic dissolution rate of chlorpropamide in cyclodextrin inclusion complexe was about 51 times ( α-cyclodextrin inclusion complex) and 12 times ( β-cyclodextrin inclusion complex) larger than that of intact chlorpropamide. | - |
dc.description.tableofcontents | 목차 = ⅲ 論文槪要 = ⅷ Ⅰ. 序論 = 1 Ⅱ. 實驗 및 方法 = 5 1. 試藥 = 5 2. 試驗機器 = 5 3. 實驗方法 = 5 Ⅲ. 結果 및 考察 = 9 Ⅳ. 結論 = 35 參考文獻 = 36 ABSTRACT = 40 | - |
dc.format | application/pdf | - |
dc.format.extent | 975201 bytes | - |
dc.language | kor | - |
dc.publisher | 이화여자대학교 대학원 | - |
dc.subject | Chlorpropamide | - |
dc.subject | Cyclodextins | - |
dc.subject | Inclusion Complex | - |
dc.title | Chlorpropamide의 Cyclodextins와의 Inclusion Complex에 관한 연구 | - |
dc.type | Master's Thesis | - |
dc.title.translated | INCLUSION COMPLEXATION OF CHLORPROPAMIDE WITH CYCLODEXTRINS IN AQUEOUS SOLUTION AND IN THE SOLID STATE | - |
dc.creator.othername | Jeong, Kyeong Hye | - |
dc.format.page | viii, 41 p. | - |
dc.identifier.thesisdegree | Master | - |
dc.identifier.major | 대학원 약학과 | - |
dc.date.awarded | 1986. 2 | - |