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신장과 혈청 Creatinine 농도를 이용한 신생아 사구체여과율의 측정에 관한 연구
- 신장과 혈청 Creatinine 농도를 이용한 신생아 사구체여과율의 측정에 관한 연구
- Other Titles
- Estimation of Glomerular Filtration Rate from Plasma Creatinice and Height in Premature and Fullterm Neonates
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- 대학원 의학과
- 신장; 혈청; Creatinine; 신생아; 사구체여과율
- 이화여자대학교 대학원
- In clinical practice, creatinine clearance (Ccr) remains the most commonly used laboratory assessment of glomerular function despite methodological and technical problems of urine collection.
Schwartz et at. in 1976, reported that m accurate estimate of glomerular filtration rate (GFR) could be obtained from the simple determinations of plasma creatinine (Pcr) and body length (L) : GFR (ml/min/1.73.㎝) = k·L(㎝)/Pcr(ml/100ml), (k=constant).
The purpose of this investigation is to compare neonatal GFR estimated by Ccr with that calculated by the formula: GFR=k·L/Pcr, (k=constant).
The subjectes of this study were 17 premature and 22 full term male neonates admitted to our nursery without any medical or renal problem. The concentration of creatinine has been measured by Jaffe reaction. The constant 0.55 derived from Zacchello (1982) was used for the formala: GFR=k·L/Pcr, (k=constant) to compare with Ccr.
The results obtained show ;
1. For premature neonates (< gestational age 34 weeks), the correlation between 24 hour Ccr determinations (average value; 15.73±5.25 m1/min/1.73㎡) and GFR estimated by the formula: 0.55·L/Pcr (average value: 21.03±5.50 ml/min/1.73㎡) is statistically not significant.
2. For premature neonates (gestational age 34-36 weeks), the correlation between 24hour Ccr determinations (average value: 26.52±6.95 ml/min/1.73㎡) and GFR estimated by the formula: 0.55·L/Pcr(average value : 22.42±6.71 ml/min/1.73㎡) is statistically not significant.
3. For fullterm neonates (gestational age 37∼42 weeks), the correlation between 24hour Ccr determinations (average value 32.72±11.20 ml/min/1.73㎡) and GFR estimated by the formula: 0.55·L/Pcr (average value: 36.38±11.78 ml/min/1.73㎡) is highly significant (r=0.65, P < 0.001).
4. The constant 0.55 derived from Zacchello (1982) for the formula: GFR=k·L/Pcr, is appropriate for fullterm neonate, but cannot be used for premature neonate. The values for k derived from our data are 0.43 for premature neonate (
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