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Rifamycin SV 誘導體의 合成에 關한 硏究

Title
Rifamycin SV 誘導體의 合成에 關한 硏究
Other Titles
Studies on the synthesis of Rifamycin SV derivative
Authors
洪起淑.
Issue Date
1975
Department/Major
대학원 화학과
Keywords
Rifamycin SV유도체합성
Publisher
이화여자대학교 대학원
Degree
Master
Abstract
3-formyl rifamycin sv의 -CHO기와 D-2-amino-1-but anol의 -NH₂기 사이에서 Schiff base를 새로 합성하였으며 이것은 흑자색의 결정이었다. ◁그림 삽입▷(원문을 참조하세요) 이 Schiff base의 λmax은 345mμ와 555mμ에 있으며 쉽게 가수분해되어 3-formyl rifamycin SV와 D-2-amino-1-butanol로 되돌아가는 불안정한 화합물이었다. 그러나 이 Schiff base를 환원하면 매우 안정된 화합물이 되었으며 그 λmax은 315mμ와 445mμ에 있었다. 결합시켜 Rifampicine보다 더 항균력이 강한 것으로 예상되는 Schiff base인 3-(1-hydroxy-2-n-butanylimino methyl)-rifamycin SV를 합성하고자 연구하였다. 그 결과를 보고하고자 한다.;Studies on the Synthesis of Rifamycin SV Derivative The new derivative of 3-formyl rifamycin SV, an antibiotic, was synthesized from the -CHO group of 3-formyl rifamycin SV and the -NH₂ group of D-2-amino-1-butanol, The results were as follows; 1. The desired compound was most effectively synthesized when it was reacted for 1 hour at 20-25℃ and in the mole ratio 1 : 1 between 3-formyl rifamycin SV and D-2-amino-1-butanol. 2. The product was dark violet crystal, very unstable, and its maximum absorption was 345mμ, 555mμ. 3. By reduction of the product, it was very stable and its maximun absorption was 315mμ, 445mμ. 4. The new synthesized schiff base is regarded as 3-(1-hydroxy-2-n-butanylimino methyl)-rifamycin SV.
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일반대학원 > 화학·나노과학과 > Theses_Master
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