View : 171 Download: 0
Rifamycin SV 誘導體의 合成에 關한 硏究
- Rifamycin SV 誘導體의 合成에 關한 硏究
- Other Titles
- Studies on the synthesis of Rifamycin SV derivative
- Issue Date
- 대학원 화학과
- Rifamycin SV; 유도체; 합성
- 이화여자대학교 대학원
- 3-formyl rifamycin sv의 -CHO기와 D-2-amino-1-but anol의 -NH₂기 사이에서 Schiff base를 새로 합성하였으며 이것은 흑자색의 결정이었다.
◁그림 삽입▷(원문을 참조하세요)
이 Schiff base의 λmax은 345mμ와 555mμ에 있으며 쉽게 가수분해되어 3-formyl rifamycin SV와 D-2-amino-1-butanol로 되돌아가는 불안정한 화합물이었다. 그러나 이 Schiff base를 환원하면 매우 안정된 화합물이 되었으며 그 λmax은 315mμ와 445mμ에 있었다.
결합시켜 Rifampicine보다 더 항균력이 강한 것으로 예상되는 Schiff base인 3-(1-hydroxy-2-n-butanylimino methyl)-rifamycin SV를 합성하고자 연구하였다. 그 결과를 보고하고자 한다.;Studies on the Synthesis of Rifamycin SV Derivative
The new derivative of 3-formyl rifamycin SV, an antibiotic, was synthesized from the -CHO group of 3-formyl rifamycin SV and the -NH₂ group of D-2-amino-1-butanol,
The results were as follows;
1. The desired compound was most effectively synthesized when it was reacted for 1 hour at 20-25℃ and in the mole ratio 1 : 1 between 3-formyl rifamycin SV and D-2-amino-1-butanol.
2. The product was dark violet crystal, very unstable, and its maximum absorption was 345mμ, 555mμ.
3. By reduction of the product, it was very stable and its maximun absorption was 315mμ, 445mμ.
4. The new synthesized schiff base is regarded as 3-(1-hydroxy-2-n-butanylimino methyl)-rifamycin SV.
- Show the fulltext
- Appears in Collections:
- 일반대학원 > 화학·나노과학과 > Theses_Master
- Files in This Item:
There are no files associated with this item.
- RIS (EndNote)
- XLS (Excel)
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.