View : 23 Download: 0

Synthesis and Characterization of Water Soluble Phosphazene Trimer-Taxol Ion Pair Adducts and Conjugates

Title
Synthesis and Characterization of Water Soluble Phosphazene Trimer-Taxol Ion Pair Adducts and Conjugates
Authors
유진희
Issue Date
2005
Department/Major
대학원 나노과학부
Keywords
phosphazenephosphazene trimerbiodegradablepaclitaxeloligomeric micelleion pair adductdrug conjugatecritical micelle concentrationcytotoxicity
Publisher
이화여자대학교 대학원
Degree
Master
Advisors
손연수
Abstract
Paclitaxel (Taxol) is a diterpenoid isolated from Taxus brevifolia, used clinically for treatment of ovarian and breast cancer. Due to its aqueous insolubility it is administered dissolved in ethanol and Cremophore EL(polyethoxylated caster oil), which has serious side effects. Water soluble cyclotriphosphazene derivatives have been studied in order to improve water solubility and the chemotherapeutical potency of paclitaxel. Cyclotriphosphazene derivatives were synthesized by stepwise nucleophilic substitutions of hexachlorocyclotriphosphazene with a hydrophilic poly(ethylene glycol) as a solubilizing group and lysine as a spacer group. They were found to form a micelle in the presence of 2′-succinyl taxol. It is presumed that the cyclic trimer may form an ion pair adduct with carboxylic acid of 2′-succinyl taxol through the alpha-amine group of lysine. We also synthesized water soluble cyclotriphosphazene taxol conjugates. The in vitro cytotoxic activities of IPA and conjugate are very low.
Fulltext
Show the fulltext
Appears in Collections:
일반대학원 > 화학·나노과학과 > Theses_Master
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE