DSpace at EWHA자연과학대학화학·나노과학전공Journal papers
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dc.contributor.author윤주영*
dc.contributor.author박재홍*
dc.date.accessioned2025-10-29T16:31:09Z-
dc.date.available2025-10-29T16:31:09Z-
dc.date.issued2025*
dc.identifier.isbn9781118774205*
dc.identifier.isbn9781118773598*
dc.identifier.issn2192-2659*
dc.identifier.otherOAK-38057*
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/273206-
dc.description.abstractTheranostic nanosensitizers with combined near-infrared (NIR) fluorescence imaging and sono-photodynamic effects have great potential for use in the personalized treatment of deep-seated tumors. However, developing effective nanosensitizers for NIR fluorescence image-guided sono-photodynamic therapy remains a considerable challenge, including the low generation efficacy of reactive oxygen species (ROS), poor photostability, and the absence of cancer specificity. Herein, a novel heavy atom-free nanosensitizer is developed, which exhibits intense NIR fluorescence, high ROS generation efficiency, and improved aqueous stability. By conjugating a bulky and electron-rich group, 4-(1,2,2-triphenylvinyl)-1,1′-biphenyl (TPE), to the IR820 backbone, the resulting IR820 bearing TPE (IR820-TPE) effectively generates ROS via type I and II photochemical mechanisms under 808 nm laser irradiation. Moreover, TPE conjugation considerably increases the sono-photodynamic performance of IR820. To improve the intracellular delivery and tumor-targeting ability of IR820-TPE, biotin-conjugated exosome (B-Exo) is used as a natural nanocarrier. In vitro studies demonstrate the outstanding therapeutic performance of IR820-TPE-loaded B-Exo (IR820-TPE@B-Exo) in synergistic sono-photodynamic cancer therapy. In vivo studies reveal that IR820-TPE@B-Exo shows enhanced tumor accumulation, strong fluorescence signals, and effective sono-photodynamic therapeutic activity with high biosafety. This work demonstrates that IR820-TPE@B-Exo is a promising sono-phototheranostic agent for safe and targeted cancer therapy and NIR fluorescence imaging. © 2025 Elsevier B.V., All rights reserved.*
dc.languageEnglish*
dc.publisherJohn Wiley and Sons Inc*
dc.subjectCancer Treatment*
dc.subjectExosome*
dc.subjectHeptamethine Cyanine*
dc.subjectReactive Oxygen Species*
dc.subjectSensitizer*
dc.subjectSono-photodynamic Therapy*
dc.subjectCaspase 3*
dc.subjectCaspase 7*
dc.subjectPhotosensitizing Agents*
dc.subjectH10-uv*
dc.subjectNano-zs*
dc.subjectTalos F200x*
dc.subjectTds3052b*
dc.subjectBiocompatibility*
dc.subjectComputerized Tomography*
dc.subjectFluorescence Imaging*
dc.subjectInfrared Imaging*
dc.subjectIrradiation*
dc.subjectLight Sensitive Materials*
dc.subjectNanoclay*
dc.subjectNanocomposites*
dc.subjectPhotodynamic Therapy*
dc.subjectTheranostics*
dc.subjectExosomes*
dc.subjectHeavy Atoms*
dc.subjectNanosensitizer*
dc.subjectNear-infrared Fluorescence*
dc.subjectNear-infrared Fluorescence Imaging*
dc.subjectPerformance*
dc.subjectSensitiser*
dc.subjectTumors*
dc.subjectReactive Oxygen Metabolite*
dc.subjectNanoparticle*
dc.subjectPhotosensitizing Agent*
dc.subjectAnimal Experiment*
dc.subjectAnimal Model*
dc.subjectAnimal Tissue*
dc.subjectAntineoplastic Activity*
dc.subjectApoptosis*
dc.subjectArticle*
dc.subjectBiosafety*
dc.subjectBody Weight*
dc.subjectCarbon Nuclear Magnetic Resonance*
dc.subjectCell Death*
dc.subjectCell Viability*
dc.subjectControlled Study*
dc.subjectCytotoxicity*
dc.subjectDynamics*
dc.subjectElectron Spin Resonance*
dc.subjectFluorescence Intensity*
dc.subjectFunctional Near-infrared Spectroscopy*
dc.subjectHek293t Cell Line*
dc.subjectHuman*
dc.subjectHuman Cell*
dc.subjectHypoxia*
dc.subjectMale*
dc.subjectMcf-7 Cell Line*
dc.subjectMouse*
dc.subjectMtt Assay*
dc.subjectNonhuman*
dc.subjectProton Nuclear Magnetic Resonance*
dc.subjectReticuloendothelial System*
dc.subjectSensitization*
dc.subjectSolid Tumor*
dc.subjectTransient Absorption Spectroscopy*
dc.subjectTransmission Electron Microscopy*
dc.subjectTumor Growth*
dc.subjectTumor Targeted Exosome*
dc.subjectTumor Volume*
dc.subjectUltraviolet Visible Spectroscopy*
dc.subjectWestern Blotting*
dc.subjectAnimal*
dc.subjectBagg Albino Mouse*
dc.subjectChemistry*
dc.subjectDrug Therapy*
dc.subjectMetabolism*
dc.subjectNeoplasm*
dc.subjectNude Mouse*
dc.subjectPathology*
dc.subjectPhotochemotherapy*
dc.subjectProcedures*
dc.subjectTherapy*
dc.subjectTumor Cell Line*
dc.subjectAnimals*
dc.subjectCell Line, Tumor*
dc.subjectHumans*
dc.subjectMice*
dc.subjectMice, Inbred Balb C*
dc.subjectMice, Nude*
dc.subjectNanoparticles*
dc.subjectNeoplasms*
dc.titleTumor-Targeted Exosome-Based Heavy Atom-Free Nanosensitizers With Long-Lived Excited States for Safe and Effective Sono-Photodynamic Therapy of Solid Tumors*
dc.typeArticle*
dc.relation.issue18*
dc.relation.volume14*
dc.relation.indexSCOPUS*
dc.relation.journaltitleAdvanced Healthcare Materials*
dc.identifier.doi10.1002/adhm.202500927*
dc.identifier.wosidWOS:001457620100001*
dc.identifier.scopusid2-s2.0-105001874352*
dc.author.googleNguyen V.N.*
dc.author.googleNguyen Cao T.G.*
dc.author.googleJeong H.*
dc.author.googleTruong Hoang Q.*
dc.author.googlePham B.T.T.*
dc.author.googleBang J.*
dc.author.googleKoh C.*
dc.author.googleKang J.*
dc.author.googleLee J.*
dc.author.googleWu X.*
dc.contributor.scopusid윤주영(7403587371)*
dc.contributor.scopusid박재홍(54391574900)*
dc.date.modifydate20260811142459*
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Adv Healthcare Materials - 2025 - Nguyen - Tumor‐Targeted Exosome‐Based Heavy Atom‐Free Nanosensitizers With Long‐Lived.pdf(6.5 MB) Download
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