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dc.contributor.author안영호*
dc.date.accessioned2025-08-07T07:11:17Z-
dc.date.available2025-08-07T07:11:17Z-
dc.date.issued2025*
dc.identifier.issn1016-8478*
dc.identifier.otherOAK-37426*
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/272174-
dc.description.abstractMicroRNAs (miRNAs) are key regulators of cancer pathogenesis, and their expression is often dysregulated in cancer cells. The role of miR-196a-5p has been investigated in various types of cancers. However, it is relatively less understood in B-cell malignancies. This study aimed to investigate the role of miR-196a-5p in B cells by using a human diffuse large B-cell lymphoma cell line, SU-DHL-6, and mouse B lymphocytes. The enforced expression of miR-196a in SU-DHL-6 cells increased daunorubicin-mediated apoptosis. Luciferase assay revealed that FOXO1 was a direct target of miR-196a-5p in SU-DHL-6 cells. The mRNA and protein expression of FOXO1 was downregulated in miR-196a-overexpressing SU-DHL-6 cells. In addition, miR-196a-5p was highly expressed in mouse bone marrow cells, compared with that of splenic B cells, and FOXO1 expression was negatively correlated with miR-196a-5p level. miR-196a-5p was upregulated by B-cell receptor stimulation, which was inversely correlated with FOXO1 expression in splenic B cells. Apoptosis was increased when miR-196a-5p was upregulated in murine primary B cells. These results identify miR-196a-5p as a post-transcriptional regulator of FOXO1 and indicate its importance in regulating B-cell malignancies and activation. © 2025 Elsevier B.V., All rights reserved.*
dc.languageEnglish*
dc.publisherElsevier B.V.*
dc.subjectApoptosis*
dc.subjectB-cell Activation*
dc.subjectB-cell Lymphoma*
dc.subjectFoxo1*
dc.subjectMicrorna-196a-5p*
dc.subjectCaspase 3*
dc.subjectCaspase 7*
dc.subjectDaunorubicin*
dc.subjectForkhead Box Protein O1*
dc.subjectFoxo1 Protein, Human*
dc.subjectMicrornas*
dc.subjectMirn196 Microrna, Human*
dc.subjectB Lymphocyte Receptor*
dc.subjectMessenger Rna*
dc.subjectMicrorna*
dc.subjectTranscription Factor Fkhr*
dc.subjectAnimal Model*
dc.subjectArticle*
dc.subjectB Cell Lymphoma*
dc.subjectB Lymphocyte*
dc.subjectB Lymphocyte Activation*
dc.subjectBone Marrow Cell*
dc.subjectCell Viability Assay*
dc.subjectDown Regulation*
dc.subjectFlow Cytometry*
dc.subjectGene Expression*
dc.subjectHuman*
dc.subjectHuman Cell*
dc.subjectLuciferase Assay*
dc.subjectMouse*
dc.subjectMutagenesis*
dc.subjectNonhuman*
dc.subjectProtein Expression*
dc.subjectReal Time Reverse Transcription Polymerase Chain Reaction*
dc.subjectSplenic B Cell*
dc.subjectSu-dhl-6 Cell Line*
dc.subjectUpregulation*
dc.subjectAnimal*
dc.subjectGene Expression Regulation*
dc.subjectGenetics*
dc.subjectMetabolism*
dc.subjectTumor Cell Line*
dc.subjectAnimals*
dc.subjectB-lymphocytes*
dc.subjectCell Line, Tumor*
dc.subjectDown-regulation*
dc.subjectGene Expression Regulation, Neoplastic*
dc.subjectHumans*
dc.subjectMice*
dc.titleMicroRNA-196a increases apoptosis in B cells through downregulation of FOXO1*
dc.typeArticle*
dc.relation.issue7*
dc.relation.volume48*
dc.relation.indexSCIE*
dc.relation.indexSCOPUS*
dc.relation.indexKCI*
dc.relation.journaltitleMolecules and Cells*
dc.identifier.doi10.1016/j.mocell.2025.100223*
dc.identifier.wosidWOS:001507599400001*
dc.identifier.scopusid2-s2.0-105007240243*
dc.author.googleKim S.*
dc.author.googleHan M.*
dc.author.googleHwang H.*
dc.author.googleAhn Y.*
dc.author.googleIm H.*
dc.author.googleHwang S.*
dc.author.googleKoh K.*
dc.author.googleKim N.*
dc.contributor.scopusid안영호(7202402440)*
dc.date.modifydate20260702152437*
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