Artificial Intelligence-Driven Volumetric Analysis of Muscle Mass as a Predictor of Tumor Response to Neoadjuvant Chemoradiotherapy in Patients with Rectal Cancer

Abstract

Background/Objectives: Artificial intelligence (AI)-based volumetric measurements for assessing sarcopenia are expected to offer comprehensive insight into three-dimensional muscle volume and distribution. Therefore, we investigated the role of sarcopenia using computed tomography (CT)-based automated AI volumetric muscle measurements in predicting neoadjuvant chemoradiotherapy (nCRT) response and prognosis in patients with rectal cancer who underwent nCRT. Methods: We retrospectively analyzed the data of patients who underwent nCRT followed by curative resection between March 2010 and August 2021. Sarcopenia was defined using the Q1 cutoff value of the volumetric skeletal muscle index (SMI). The association between pre-nCRT volumetric sarcopenia and nCRT response was analyzed using logistic regression. A Cox proportional hazards model was used to identify the prognostic value of the pre- and post-nCRT volumetric SMIs. Results: Notably, 22 (25.6%) of the 86 patients had volumetric sarcopenia. The sarcopenia group showed a poorer nCRT response than the non-sarcopenia group. Pre-nCRT sarcopenia was a significant predictor of poor nCRT response (OR, 0.34 [95% CI, 0.12–0.96]; p = 0.041). Furthermore, an increased volumetric SMI during nCRT was a more significant prognostic factor on recurrence-free survival (aHR, 0.26 [95% CI, 0.08–0.83]; p = 0.023) and overall survival (aHR, 0.41 [95% CI, 0.17–0.99]; p = 0.049) than a decreased SMI. Conclusions: Volumetric sarcopenia can be used to predict poor nCRT response. A reduction in volumetric sarcopenia can be a poor prognostic factor in patients with rectal cancer who undergo nCRT. © 2024 by the authors.