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Apigenin's Therapeutic Potential Against Viral Infection

Title
Apigenin's Therapeutic Potential Against Viral Infection
Authors
Lee, In-GuLee, JeonghyeonHong, So-HeeSeo, Young-Jin
Ewha Authors
홍소희
SCOPUS Author ID
홍소희scopus
Issue Date
2023
Journal Title
FRONTIERS IN BIOSCIENCE-LANDMARK
ISSN
2768-6701JCR Link

2768-6698JCR Link
Citation
FRONTIERS IN BIOSCIENCE-LANDMARK vol. 28, no. 10
Keywords
flavonoids4 ',5,7-trihydroxyflavoneantiviral drugsinfluenzaphytochemicals
Publisher
IMR PRESS
Indexed
SCIE; SCOPUS WOS
Document Type
Review
Abstract
Several antiviral drugs are clinically approved to treat influenza that is a highly prevalent acute respiratory disease. However, emerging drug-resistant virus strains undermine treatment efficacy, highlighting the exigency for novel antiviral drugs to counter these drug-resistant strains. Plants and their derivates have been historically utilized as medicinal remedies, and extensive studies have evidenced the antiviral potential of phytochemicals. Notably, apigenin is a predominant flavonoid with minimal toxicity and substantial therapeutic effects in various disease models. Despite its many anti-inflammatory, anti-oxidant, anti-cancer, anti-bacterial, and other beneficial bioactivities, existing reviews have yet to focus on apigenin's antiviral effects. Therefore, this review elucidates apigenin's therapeutic and antiviral properties in vitro and in vivo, discussing its mode of action and future prospects. Apigenin's remarkable inhibition by modulating multiple mechanisms against viruses has promising potential for novel plant-derived antiviral drugs and further clinical study developments.
DOI
10.31083/j.fbl2810237|http://dx.doi.org/10.31083/j.fbl2810237
Appears in Collections:
의과대학 > 의학과 > Journal papers
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