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Metal–organic frameworks as a fluorescent probe for detection of pathogenic biomarkers in human urine
- Title
- Metal–organic frameworks as a fluorescent probe for detection of pathogenic biomarkers in human urine
- Authors
- Jeong; Seyeon; Moon; Hoi Ri
- Ewha Authors
- 문회리
- SCOPUS Author ID
- 문회리
![scopus](/images/layout/icon2.png)
- Issue Date
- 2024
- Journal Title
- Bulletin of the Korean Chemical Society
- ISSN
- 0253-2964
- Citation
- Bulletin of the Korean Chemical Society vol. 45, no. 4, pp. 308 - 316
- Keywords
- biomarker; biosensor; fluorescent probe; metal–organic framework; urine
- Publisher
- John Wiley and Sons Inc
- Indexed
- SCIE; SCOPUS
![scopus](/images/layout/scopus2.gif)
- Document Type
- Review
- Abstract
- Metal–organic frameworks (MOFs) are actively explored as sensing materials owing to their high porosity, substantial surface area, and structural diversity, providing diverse chemical and physical properties. Their fluorescent characteristics are pivotal, enabling MOFs to function as probes for detecting specific target molecules. Unlike conventional disease diagnosis methods such as biopsies or blood collection, the detection of pathogenic biomarkers in human urine is conventional and less risky. While mass spectroscopy identifies proteins and metabolites in urine at high costs, MOF test papers offer a convenient solution. These papers confirm the existence of the target molecules through naked-eye observation upon UV light irradiation at specific wavelengths. MOF-based fluorescent probes facilitate disease diagnosis, including pheochromocytoma, toluene exposure, vitamin deficiencies, gout, hyperuricemia, cancers, body disorders, and teratogenicity, with low detection limits. This review delves into recent developments in MOF fluorescent probes, covering synthesis, emission spectra, and sensing mechanisms. © 2024 Korean Chemical Society, Seoul & Wiley-VCH GmbH.
- DOI
- 10.1002/bkcs.12827
- Appears in Collections:
- 자연과학대학 > 화학·나노과학전공 > Journal papers
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