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Association of smoking with amyotrophic lateral sclerosis: A systematic review, meta-analysis, and dose-response analysis

Title
Association of smoking with amyotrophic lateral sclerosis: A systematic review, meta-analysis, and dose-response analysis
Authors
KimKihunKoDai SikJin-WooLeeDongjunSonEunjeongHyun-WooSongTae-JinYun Hak
Ewha Authors
송태진김진우
SCOPUS Author ID
송태진scopus; 김진우scopus
Issue Date
2024
Journal Title
Tobacco Induced Diseases
ISSN
1617-9625JCR Link
Citation
Tobacco Induced Diseases vol. 22
Keywords
amyotrophic lateral sclerosisdose-response analysismeta-analysissmokingsystematic review
Publisher
European Publishing
Indexed
SCIE; SSCI; SCOPUS WOS scopus
Document Type
Review
Abstract
INTRODUCTION Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder primarily affecting the voluntary motor nervous system. Several observational studies have provided conflicting results regarding the association between smoking and ALS. Therefore, our objective was to investigate this association through a systematic review, meta-analysis, and dose-response analysis. METHODS On 16 January 2023, we initially extracted records from medical databases, which included Medline, Embase, Web of Science, Scopus, and ScienceDirect. We included case-control and cohort studies as eligible studies. Subgroup analyses were performed based on sex, study design, and current smoking. Restricted cubic-spline analysis was utilized to assess the dose-response relationship between smoking (pack-years) and ALS. RESULTS Twenty-eight case-control and four cohort studies met the inclusion criteria. The unadjusted OR for the overall association between smoking and ALS was 1.14 (95% CI: 1.06–1.22, I2=44%, p<0.001), and the adjusted OR (AOR) was 1.12 (95% CI: 1.03–1.21, I2=49%, p=0.009). Subgroup analysis revealed a more pronounced association among current smokers, with an AOR of 1.28 (95% CI: 1.10–1.49, I2=66%, p<0.001) and AOR of 1.28 (95% CI: 1.10–1.48, I2=58%, p=0.001). In the dose-response analysis, the non-linear model revealed an inverted U-shaped curve. CONCLUSIONS Our study provides evidence of a positive relationship between smoking and the risk of ALS. To mitigate the risk of developing ALS, discontinuing smoking, which is a modifiable risk factor, may be crucial. © 2024 Kim K. et al.
DOI
10.18332/tid/175731
Appears in Collections:
의과대학 > 의학과 > Journal papers
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