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Retinestatin, a Polyol Polyketide from a Termite Nest-Derived Streptomyces sp.
- Title
- Retinestatin, a Polyol Polyketide from a Termite Nest-Derived Streptomyces sp.
- Authors
- Huynh; Thanh-Hau; Kim; Hee Kyung; Lee; Jayho; Ban; Yeon Hee; Jang; Yong-Joon; Heo; Bo Eun; Nguyen; Thanh Quang; An; Joon Soo; Kwon; Yun; Nam; Sang-Jip; Jichan; Oh; Ki-Bong; Shin; Min-Kyoo; Dong-Chan
- Ewha Authors
- 남상집
- SCOPUS Author ID
- 남상집
- Issue Date
- 2024
- Journal Title
- Journal of Natural Products
- ISSN
- 0163-3864
- Citation
- Journal of Natural Products vol. 87, no. 3, pp. 591 - 599
- Publisher
- American Chemical Society
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- A new polyol polyketide, named retinestatin (1), was obtained and characterized from the culture of a Streptomyces strain, which was isolated from a subterranean nest of the termite Reticulitermes speratus kyushuensis Morimoto. The planar structure of 1 was elucidated on the basis of the cumulative analysis of ultraviolet, infrared, mass spectrometry, and nuclear magnetic resonance spectroscopic data. The absolute configuration of 1 at 12 chiral centers was successfully assigned by employing a J-based configuration analysis in combination with ROESY correlations, a quantum mechanics-based computational approach to calculate NMR chemical shifts, and a 3 min flash esterification by Mosher’s reagents followed by NMR analysis. Biological evaluation of retinestatin (1) using an in vitro model of Parkinson’s disease revealed that 1 protected SH-SY5Y dopaminergic cells from MPP+-induced cytotoxicity, indicating its neuroprotective effects. © 2024 American Chemical Society and American Society of Pharmacognosy.
- DOI
- 10.1021/acs.jnatprod.3c01043
- Appears in Collections:
- 자연과학대학 > 화학·나노과학전공 > Journal papers
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