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Amygdala electrical stimulation for operant conditioning in rat navigation

Title
Amygdala electrical stimulation for operant conditioning in rat navigation
Authors
LeeYoujinKimSoonyoungChoYoon KyungKongChanhoChangJin WooJunSang Beom
Ewha Authors
전상범
SCOPUS Author ID
전상범scopus
Issue Date
2024
Journal Title
Biomedical Engineering Letters
ISSN
2093-9868JCR Link
Citation
Biomedical Engineering Letters vol. 14, no. 2, pp. 291 - 306
Keywords
AmygdalaElectrical stimulationMedial forebrain bundleNeuromodulation
Publisher
Springer Verlag
Indexed
SCIE; SCOPUS; KCI scopus
Document Type
Article
Abstract
There have been several attempts to navigate the locomotion of animals by neuromodulation. The most common method is animal training with electrical brain stimulation for directional cues and rewards; the basic principle is to activate dopamine-mediated neural reward pathways such as the medial forebrain bundle (MFB) when the animal correctly follows the external commands. In this study, the amygdala, which is the brain region responsible for fear modulation, was targeted for punishment training. The brain regions of MFB, amygdala, and barrel cortex were electrically stimulated for reward, punishment, and directional cues, respectively. Electrical stimulation was applied to the amygdala of rats when they failed to follow directional commands. First, two different amygdala regions, i.e., basolateral amygdala (BLA) and central amygdala (CeA), were stimulated and compared in terms of behavior responses, success and correction rates for training, and gene expression for learning and memory. Then, the training was performed in three groups: group R (MFB stimulation for reward), group P (BLA stimulation for punishment), and group RP (both MFB and BLA stimulation for reward and punishment). In group P, after the training, RNA sequencing was conducted to detect gene expression and demonstrate the effect of punishment learning. Group P showed higher success rates than group R, and group RP exhibited the most effective locomotion control among the three groups. Gene expression results imply that BLA stimulation can be more effective as a punishment in the learning process than CeA stimulation. We developed a new method to navigate rat locomotion behaviors by applying amygdala stimulation. © Korean Society of Medical and Biological Engineering 2023.
DOI
10.1007/s13534-023-00336-1
Appears in Collections:
공과대학 > 전자전기공학전공 > Journal papers
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