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High platelet reactivity strongly predicts early stent thrombosis in patients with drug-eluting stent implantation
- Title
- High platelet reactivity strongly predicts early stent thrombosis in patients with drug-eluting stent implantation
- Authors
- Lim; Subin; Hong; Soon Jun; Kim; Ju Hyeon; Cha; Jung-Joon; Joo; Hyung Joon; Park; Jae Hyoung; Yu; Cheol Woong; Byeong-Keuk; Chang; Kiyuk; Yongwhi; Song; Young Bin; Ahn; Sung Gyun; Suh; Jung-Won; Lee; Sang Yeub; Cho; Jung Rae; Her; Ae-Young; Jeong; Young-Hoon; Hyo-Soo; Moo Hyun; Shin; Eun-Seok; Do-Sun; Hyun Kuk; Jung Hee; Byoung Kwon; Weon; Kyung Woo; Moon; Jae Yeon; Kwon; Osung; Chan Joon; Hyun-Woong; Chang Hoon; Jang; Woo Jin; Jin; Han-Young; Chon; Min Ku; Choi; Ki Hong; Han; Dong Hoon; Kang; Min Gyu; Jeehoon; Ki; You Jeong; Jin Sup; Seung-Jun; Seung Hun; Jong-Young; Sung Won; Jon; Bae; Jang-Whan; You; Seng Chan; Myung Ho
- Ewha Authors
- 장우진
- SCOPUS Author ID
- 장우진
- Issue Date
- 2024
- Journal Title
- Scientific Reports
- ISSN
- 2045-2322
- Citation
- Scientific Reports vol. 14, no. 1
- Publisher
- Nature Research
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Stent thrombosis (ST) is a fatal complication after percutaneous coronary intervention (PCI). The association between P2Y12 reaction unit (PRU) level and stent thrombosis occurrence remains unclear. Based on the multicenter, observational PTRG-DES (Platelet function and genoType-Related long-term proGnosis in DES-treated patients) registry of patients with drug-eluting stents (DES) implantation, a total of 11,714 patients with PRU values were analyzed. We sought to identify the predictors of early stent thrombosis (EST) and compared the primary outcome, a composite of cardiac death, myocardial infarction, and revascularization, between EST and non-EST groups. EST, defined as definite ST within 1 month after index PCI, occurred in 51 patients. PRU values were significantly higher in the EST group (263.5 ± 70.8 vs. 217.5 ± 78.7, p < 0.001). In multivariable analysis, PRU ≥ 252 (OR, 5.10; 95% CI 1.58–16.46; p = 0.006) and aspirin reaction unit ≥ 414 (OR 4.85; 95% CI 1.07–21.97; p = 0.040) were independent predictors of EST. The cumulative incidence of primary composite outcome at one year was significantly higher in the EST group (38.2% vs. 3.9%, Log-rank p < 0.001). In patients treated with clopidogrel after successful DES implantation, EST was associated with higher platelet reactivities, and a greater risk of cardiovascular events. Trial Registration: clinicaltrials.gov Identifier: NCT04734028. © 2024, The Author(s).
- DOI
- 10.1038/s41598-023-50920-9
- Appears in Collections:
- 의료원 > 의료원 > Journal papers
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