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Association between substantia nigra degeneration and functional outcome in patients with basal ganglia infarction
- Title
- Association between substantia nigra degeneration and functional outcome in patients with basal ganglia infarction
- Authors
- Lee; Hyungwoo; Kijeong; Kim; Young Dae; Nam; Hyo Suk; Hye Sun; Cho; Sunghee; Heo; Ji Hoe
- Ewha Authors
- 이형우
- SCOPUS Author ID
- 이형우
- Issue Date
- 2024
- Journal Title
- European Journal of Neurology
- ISSN
- 1351-5101
- Citation
- European Journal of Neurology vol. 31, no. 2
- Keywords
- basal ganglia; outcome; prognosis; secondary degeneration; substantia nigra
- Publisher
- John Wiley and Sons Inc
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Background and purpose: Cerebral infarction in the basal ganglia may cause secondary and delayed neuronal degeneration in the substantia nigra (SN). However, the clinical significance of SN degeneration remains poorly understood. Methods: This retrospective observational study included patients with acute ischemic stroke in the basal ganglia on initial diffusion-weighted imaging who underwent follow-up diffusion-weighted imaging between 4 and 30 days after symptom onset. SN degeneration was defined as a hyperintensity lesion in the SN observed on diffusion-weighted imaging. We compared functional outcomes at 3 months between patients with and without SN degeneration. A poor outcome was defined as a score of 3–6 (functional dependence or death) on the modified Rankin Scale. Results: Of 350 patients with basal ganglia infarction (median age = 74.0 years, 53.7% male), 125 (35.7%) had SN degeneration. The proportion of functional dependence or death was 79.2% (99/125 patients) in patients with SN degeneration, which was significantly higher than that in those without SN degeneration (56.4%, 127/225 patients, p < 0.001). SN degeneration was more frequent in patients with functional dependence or death (99/226 patients, 43.8%) than in those with functional independence (26/124 patients, 21.0%, p < 0.001). Multivariable logistic regression analysis showed a significant association between SN degeneration and functional dependence or death (odds ratio = 2.91, 95% confidence interval = 1.17–7.21, p = 0.021). Conclusions: The study showed that patients with degeneration of SN were associated with functional dependence or death at 3 months, suggesting that secondary degeneration is a predictor of poor stroke outcomes and a potential therapeutic target. © 2023 The Authors. European Journal of Neurology published by John Wiley & Sons Ltd on behalf of European Academy of Neurology.
- DOI
- 10.1111/ene.16111
- Appears in Collections:
- 의료원 > 의료원 > Journal papers
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