Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 송은미 | * |
dc.date.accessioned | 2024-02-15T05:11:34Z | - |
dc.date.available | 2024-02-15T05:11:34Z | - |
dc.date.issued | 2023 | * |
dc.identifier.issn | 1011-8934 | * |
dc.identifier.issn | 1598-6357 | * |
dc.identifier.other | OAK-34453 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/267714 | - |
dc.description.abstract | Background: Few studies evaluate the epidemiology and risk factors of Clostridioides difficile infection (CDI) in Asian patients with inflammatory bowel disease (IBD). We investigated the year-end prevalence, cumulative incidence and risk factors of CDI in Asian patients with IBD using a large-scale population-based cohort in Korea. Methods: Using the National Health Insurance Service database, we identified patients with IBD and sex-and age-matched controls without IBD between 2008 and 2018. The year-end prevalence and cumulative incidence of CDI were compared among patients with Crohn's disease (CD) and ulcerative colitis (UC) with controls. The risk factors for CDI were evaluated.Results: Among the 54,836 patients with IBD and 109,178 controls, CDI occurred in 293 patients with IBD and 87 controls. The annual year-end prevalence of CDI in patients with IBD increased from 8.6/10,000 persons in 2008 to 22.3/10,000 persons in 2018. The risk of CDI was higher in both patients with CD and UC than that in the matched controls (hazard ratio [HR], 7.285; 95% confidence interval [CI], 5.388-9.851; P < 0.001 and HR, 7.487; 95% CI, 5.796-9.670; P < 0.001, respectively). Among patients with IBD, the risk factors for CDI included older age, female sex, high Charlson comorbidity index score, and IBD-related medications including oral 5-aminosalicylic acid, immunomodulatory agents, biologics, and steroids used for > 90 days. Conclusion: The risk of CDI in Korean patients with IBD was approximately seven times higher than that in controls without IBD, and the annual year-end prevalence of CDI continuously increased from 2008 to 2018. | * |
dc.language | English | * |
dc.publisher | KOREAN ACAD MEDICAL SCIENCES | * |
dc.subject | Clostridioides difficile | * |
dc.subject | Pseudomembranous Enterocolitis | * |
dc.subject | Inflammatory Bowel Diseases | * |
dc.subject | Crohn Disease | * |
dc.subject | Ulcerative Colitis | * |
dc.title | The Prevalence and Risk Factors of <i>Clostridioides difficile</i> Infection in Inflammatory Bowel Disease: 10-Year South Korean Experience Based on the National Database | * |
dc.type | Article | * |
dc.relation.issue | 47 | * |
dc.relation.volume | 38 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.index | KCI | * |
dc.relation.journaltitle | JOURNAL OF KOREAN MEDICAL SCIENCE | * |
dc.identifier.doi | 10.3346/jkms.2023.38.e359 | * |
dc.identifier.wosid | WOS:001117767200009 | * |
dc.author.google | Song, Eun Mi | * |
dc.author.google | Choi, Arum | * |
dc.author.google | Kim, Sukil | * |
dc.author.google | Jung, Sung Hoon | * |
dc.contributor.scopusid | 송은미(57193312165) | * |
dc.date.modifydate | 20240315140140 | * |