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Changes in proteinuria and the associated risks of ischemic heart disease, acute myocardial infarction, and angina pectoris in Korean population
- Title
- Changes in proteinuria and the associated risks of ischemic heart disease, acute myocardial infarction, and angina pectoris in Korean population
- Authors
- Park, Sung Keun; Jung, Ju Young; Kim, Min -Ho; Oh, Chang-Mo; Ha, Eunhee; Yang, Eun Hye; Lee, Hyo Choon; Shin, Soonsu; Hwang, Woo Yeon; Lee, Sangho; Shin, So Youn; Ryoo, Jae-Hong
- Ewha Authors
- 하은희
- SCOPUS Author ID
- 하은희
- Issue Date
- 2023
- Journal Title
- EPIDEMIOLOGY AND HEALTH
- ISSN
- 2092-7193
- Citation
- EPIDEMIOLOGY AND HEALTH vol. 45
- Keywords
- Angina pectoris; Myocardial infarction; Myocardial ischemia; Proteinuria
- Publisher
- KOREAN SOC EPIDEMIOLOGY
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Objectives: Proteinuria is widely used to predict cardiovascular risk. However, there is insufficient evidence to predict how changes in proteinuria may affect the incidence of cardiovascular disease.Methods: The study included 265,236 Korean adults who underwent health checkups in 2003-2004 and 2007-2008. They were categorized into 4 groups based on changes in proteinuria (negative: negative -> negative; resolved: proteinuria >= 1+ -> negative; incident: negative -> proteinuria >= 1+; persistent: proteinuria >= 1+ -> proteinuria >= 1+). We conducted 6 years of follow-up to identify the risks of developing ischemic heart disease (IHD), acute myocardial infarction (AMI), and angina pectoris according to changes in proteinuria. A multivariate Cox proportional-hazards model was used to calculate adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for incident IHD, AMI, and angina pectoris.Results: The IHD risk (expressed as HR [95% CI]) was the highest for persistent proteinuria, followed in descending order by incident and resolved proteinuria, compared with negative proteinuria (negative: reference, resolved: 1.211 [95% CI, 1.104 to 1.329], incident: 1.288 [95% CI, 1.184 to 1.400], and persistent: 1.578 [95% CI, 1.324 to 1.881]). The same pattern was associated with AMI (negative: reference, resolved: 1.401 [95% CI, 1.048 to 1.872], incident: 1.606 [95% CI, 1.268 to 2.035], and persistent: 2.069 [95% CI, 1.281 to 3.342]) and angina pectoris (negative: reference, resolved: 1.184 [95% CI, 1.065 to 1.316], incident: 1.275 [95% CI, 1.160 to 1.401], and persistent: 1.554 [95% CI, 1.272 to 1.899]).Conclusions: Experiencing proteinuria increased the risks of IHD, AMI, and angina pectoris even after proteinuria resolved.
- DOI
- 10.4178/epih.e2023088
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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