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Exploring the origins of decreased sound tolerance in tinnitus patients

Title
Exploring the origins of decreased sound tolerance in tinnitus patients
Authors
Kim, Eun HyeShin, Seung-HoByun, Sung WanLee, Ho Yun
Ewha Authors
변성완신승호이호윤
SCOPUS Author ID
변성완scopus; 신승호scopus
Issue Date
2023
Journal Title
FRONTIERS IN NEUROLOGY
ISSN
1664-2295JCR Link
Citation
FRONTIERS IN NEUROLOGY vol. 14
Keywords
tinnitussound intolerancehyperacusisauditory brainstem evoked potentials (ABR)otoacoustic emission (OAE)
Publisher
FRONTIERS MEDIA SA
Indexed
SCIE; SCOPUS WOS
Document Type
Article
Abstract
This study aimed to confirm the characteristics of auditory function alterations in tinnitus patients with concomitant decreased sound tolerance (ST) and provide insights for developing tailored therapeutic approaches. A retrospective analysis was conducted on patient records from a tertiary university hospital's tinnitus clinic between March 2020 and June 2023. Demographic attributes and audiological profiles were reviewed. Patients were categorized into Group 1 if loudness discomfort level test outcomes were 77 dB or below, measured using an average of frequencies from 250 Hz to 8 kHz. The remaining patients were allocated to Group 2. Among the 434 tinnitus patients, 115 (26.5%) demonstrated decreased ST and were classified as Group 1. This group exhibited higher DPOAE amplitudes (p < 0.001), shortened latency, and decreased threshold of ABR wave V bilaterally (p < 0.05). No significant disparities were observed in gender, age, tinnitus handicap inventory, visual analog scale, and pure-tone audiometry results except subjective hyperacusis. Binary logistic regression analysis utilizing the forward conditional method revealed that the difference between groups was independently linked to DPOAE response at 7,277 Hz on the left side [B = 0.093, p < 0.001, EXP(B) = 1.07, 95% CI = 1.044-1.153]. Increased DPOAE amplitude and shorter and decreased ABR wave V in tinnitus patients with decreased ST might suggest a possible association with lesions in or around the superior olivary complex or higher central auditory pathway, potentially linked to the inhibition of medial olivocochlear efferents.
DOI
10.3389/fneur.2023.1273705
Appears in Collections:
의과대학 > 의학과 > Journal papers
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