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Liquid Crystal Polymer-Based Miniaturized Fully Implantable Deep Brain Stimulator

Title
Liquid Crystal Polymer-Based Miniaturized Fully Implantable Deep Brain Stimulator
Authors
AhnSeung-HeeKohChin SuParkMinkyungJunSang BeomChangJin WooKimSung JuneJungHyun HoJeongJoonsoo
Ewha Authors
전상범
SCOPUS Author ID
전상범scopus
Issue Date
2023
Journal Title
Polymers
ISSN
2073-4360JCR Link
Citation
Polymers vol. 15, no. 22
Keywords
deep brain stimulationimplantable electronicsliquid crystal polymersvon Frey test
Publisher
Multidisciplinary Digital Publishing Institute (MDPI)
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
A significant challenge in improving the deep brain stimulation (DBS) system is the miniaturization of the device, aiming to integrate both the stimulator and the electrode into a compact unit with a wireless charging capability to reduce invasiveness. We present a miniaturized, fully implantable, and battery-free DBS system designed for rats, using a liquid crystal polymer (LCP), a biocompatible and long-term reliable material. The system integrates the simulator circuit, the receiver coil, and a 20 mm long depth-type microelectrode array in a dome-shaped LCP package that is 13 mm in diameter and 5 mm in height. Wireless powering and control via an inductive link enable device miniaturization, allowing for full implantation and, thus, the free behavior of untethered animals. The eight-channel stimulation electrode array was microfabricated on an LCP substrate to form a multilayered system substrate, which was monolithically encapsulated by a domed LCP lid using a specialized spot-welding process. The device functionality was validated via an in vivo animal experiment using a neuropathic pain model in rats. This experiment demonstrated an increase in the mechanical withdrawal threshold of the rats with microelectrical stimulation delivered using the fully implanted device, highlighting the effectiveness of the system. © 2023 by the authors.
DOI
10.3390/polym15224439
Appears in Collections:
공과대학 > 전자전기공학전공 > Journal papers
Files in This Item:
polymers-15-04439-v2.pdf(8.44 MB) Download
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