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Effect of Particulate Matter 2.5 on Fetal Growth in Male and Preterm Infants through Oxidative Stress
- Title
- Effect of Particulate Matter 2.5 on Fetal Growth in Male and Preterm Infants through Oxidative Stress
- Authors
- Park; Sunwha; Kwon; Eunjin; Lee; Gain; You; Young-Ah; Kim; Soo Min; Hur; Young Min; Jung; Sooyoung; Jee; Yongho; Mi Hye; Na; Sung Hun; Young-Han; Cho; Geum Joon; Bae; Jin-Gon; Soo-Jeong; Sun Hwa; Young Ju
- Ewha Authors
- 김영주; 박미혜; 유영아; 박선화; 허영민; 지용호
- SCOPUS Author ID
- 김영주
; 박미혜![scopus](/images/layout/icon2.png)
; 유영아
; 박선화
; 허영민
; 지용호![scopus](/images/layout/icon2.png)
- Issue Date
- 2023
- Journal Title
- Antioxidants
- ISSN
- 2076-3921
- Citation
- Antioxidants vol. 12, no. 11
- Keywords
- 8-hydroxy-2-deoxyguanosine; biomarker; indoor air; low birth weight; particulate matter; preterm birth; sex difference; small for gestational age
- Publisher
- Multidisciplinary Digital Publishing Institute (MDPI)
- Indexed
- SCIE; SCOPUS
![scopus](/images/layout/scopus2.gif)
- Document Type
- Article
- Abstract
- Particulate matter 2.5 (PM2.5) levels are associated with adverse pregnancy outcomes. In this retrospective cohort study, we examined whether the concentration of indoor PM2.5 affected pregnancy outcomes. Additionally, we evaluated biomarkers of pregnancy-related complications caused by fine dust. We collected clinical information and data based on residential addresses from the Air Korea database to assess PM2.5 exposure levels. As a multicenter prospective cohort study, we measured the indoor PM2.5 concentration and inflammatory and oxidative stress markers. The PM2.5 concentration of the low-birth-weight (LBW) delivery group was 27.21 μg/m3, which was significantly higher than that of the normal-birth-weight (NBW) group (26.23 μg/m3) (p = 0.02). When the newborns were divided by sex, the PM2.5 concentration of the LBW group was 27.89 μg/m3 in male infants, which was significantly higher than that of the NBW group (26.26 μg/m3) (p = 0.01). In the prospective study, 8-hydroxy-2-deoxyguanosine significantly increased in the high-concentration group (113.55 ng/mL, compared with 92.20 ng/mL in the low-concentration group); in the high-concentration group, the rates of preterm birth (PTB) and small size for gestational age significantly increased (p < 0.01, p = 0.01). This study showed an association between PM2.5, oxidative stress, and fetal growth, with the PTB group being more vulnerable. © 2023 by the authors.
- DOI
- 10.3390/antiox12111916
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
- Files in This Item:
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antioxidants-12-01916-v3.pdf(1.28 MB)
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