Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 권기환 | * |
dc.date.accessioned | 2023-10-19T16:31:15Z | - |
dc.date.available | 2023-10-19T16:31:15Z | - |
dc.date.issued | 2023 | * |
dc.identifier.issn | 1524-6175 | * |
dc.identifier.issn | 1751-7176 | * |
dc.identifier.other | OAK-34139 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/266277 | - |
dc.description.abstract | The authors evaluated the efficacy, safety, and characteristics of patients who respond well to standard dose triple combination therapy including chlorthalidone 25 mg with telmisartan 80 mg plus amlodipine 5 mg in hypertensive patients. This is a multicenter, double-blind, active-controlled, phase 3, randomized trial. Patients are randomized to triple combination (telmisartan 40 mg/amlodipine 5 mg/chlorthalidone 12.5 mg, TEL/AML/CHTD group) or dual combination (telmisartan 40 mg/amlodipine 5 mg, TEL/AML group) treatment and then dose up titration to TEL 80/AML5/CHTD25mg and TEL80/AML5, respectively. The primary endpoint is the change of mean sitting systolic blood pressure (MSSBP) at week 8. A Target BP achievement rate, a response rate, and the safety endpoints are also evaluated. Total 374 patients (mean age = 60.9 +/- 10.7 years, male = 78.3%) were randomized to the study. The baseline MSSBPs/diastolic BPs were 149.9 +/- 12.2/88.5 +/- 10.4 mm Hg. After 8 weeks treatment, the change of MSSBPs at week 8 are -19.1 +/- 14.9 mm Hg (TEL/AML/CHTD) and -11.4 +/- 14.7 mm Hg (TEL/AML) (p < .0001). The achievement rates of target BP (53.8% vs. 37.8%, p = .0017) and responder rate (54.8% vs. 35.6%, p = .0001) at week 8 were significantly higher in TEL/AML/CHTD. There are no serious adverse event and no one discontinued medication due to adverse event. Among the TEL 80/AML5/CHTD25mg treatment group, patients of female or age >= 65 years old showed higher rate of target BP achievement than relatively young male. (61.4 vs. 46.8%, p = .042) Our study showed standard dose triple combination of telmisartan 80 mg/amlodipine 5 mg/chlorthalidone 25 mg is efficacious and safe in treatment of primary hypertension. Target BP achievement with triple therapy would be facilitated in female or old age. | * |
dc.language | English | * |
dc.publisher | WILEY | * |
dc.subject | amlodipine | * |
dc.subject | blood pressure | * |
dc.subject | chlorthalidone | * |
dc.subject | telmisartan | * |
dc.subject | triple combination | * |
dc.title | Efficacy and safety of standard dose triple combination of telmisartan 80 mg/amlodipine 5 mg/chlorthalidone 25 mg in primary hypertension: A randomized, double-blind, active-controlled, multicenter phase 3 trial | * |
dc.type | Article | * |
dc.relation.issue | 9 | * |
dc.relation.volume | 25 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 817 | * |
dc.relation.lastpage | 827 | * |
dc.relation.journaltitle | JOURNAL OF CLINICAL HYPERTENSION | * |
dc.identifier.doi | 10.1111/jch.14707 | * |
dc.identifier.wosid | WOS:001080168200001 | * |
dc.identifier.scopusid | 2-s2.0-85168712738 | * |
dc.author.google | Cho, Eun Joo | * |
dc.author.google | Kim, Moo Hyun | * |
dc.author.google | Kim, Young-Hak | * |
dc.author.google | Chang, Kiyuk | * |
dc.author.google | Choi, Dong-Ju | * |
dc.author.google | Kang, Woong Chol | * |
dc.author.google | Shin, Jinho | * |
dc.author.google | Kim, Seong Hwan | * |
dc.author.google | Lee, Namho | * |
dc.author.google | Son, Jang Won | * |
dc.author.google | Doh, Joon-Hyung | * |
dc.author.google | Kim, Woo-Shik | * |
dc.author.google | Hong, Soon Jun | * |
dc.author.google | Rhee, Moo-Yong | * |
dc.author.google | Ahn, Youngkeun | * |
dc.author.google | Lim, Sang-Wook | * |
dc.author.google | Hong, Seung Pyo | * |
dc.author.google | Choi, So-Yeon | * |
dc.author.google | Hyon, Min Su | * |
dc.author.google | Hwang, Jin-Yong | * |
dc.author.google | Kwon, Kihwan | * |
dc.author.google | Cha, Kwang Soo | * |
dc.author.google | Ihm, Sang-Hyun | * |
dc.author.google | Lee, Jae-Hwan | * |
dc.author.google | Yoo, Byung-Su | * |
dc.author.google | Kim, Hyo-Soo | * |
dc.contributor.scopusid | 권기환(57203037966) | * |
dc.date.modifydate | 20240131144606 | * |