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Large-Scale Clinical Evaluation of Rapid Blood Culture Identification Panels for Bloodstream Infections at a Tertiary Hospital

Title
Large-Scale Clinical Evaluation of Rapid Blood Culture Identification Panels for Bloodstream Infections at a Tertiary Hospital
Authors
So M.-K.Kim S.-K.Chung H.-S.Bae J.-Y.Lee M.
Ewha Authors
이미애정혜선배지윤김수경소민경
SCOPUS Author ID
이미애scopus; 정혜선scopus; 배지윤scopus; 김수경scopusscopusscopus; 소민경scopus
Issue Date
2023
Journal Title
Diagnostics
ISSN
2075-4418JCR Link
Citation
Diagnostics vol. 13, no. 6
Keywords
blood culture identificationbloodstream infectionsFilmArray
Publisher
MDPI
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
The prompt implementation of optimal antibacterial therapy through the rapid identification of the causative organisms is essential for improving outcomes for critically ill patients with bloodstream infections. We evaluated the clinical performance of the FilmArray blood culture identification (BCID) panel for rapidly identifying causative pathogens in the bloodstream using large-scale clinical samples. We analyzed the results of identification using a BCID panel performed on 2005 positive blood culture bottles from September 2019 to June 2022. Pathogen detection efficiency and interval from Gram staining to identification using the BCID panel were compared to those of conventional identification systems—VITEK MS MALDI-TOF Mass Spectrometer and Vitek2—and antibiotic susceptibility testing—Vitek2. We detected 2167 isolates from 2005 positive blood culture bottles. In these isolates, the BCID panel showed 93% full agreement—both organisms and antimicrobial resistance genes were matched, and no off-target organisms were detected. Species-level discordance was found in 0.6% of tests. Sixty-five isolates (3.0%) were only detected by BCID, whereas 22 isolates (1.0%) from the on-target panel were not detected by BCID. This large-scale study demonstrated that the BCID panel was a reliable and rapid identification method for directly identifying bloodstream pathogens in a positive blood culture. © 2023 by the authors.
DOI
10.3390/diagnostics13061177
Appears in Collections:
의과대학 > 의학과 > Journal papers
Files in This Item:
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