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A nationwide study of compliance of venoactive drugs in chronic venous disease patients
- Title
- A nationwide study of compliance of venoactive drugs in chronic venous disease patients
- Authors
- Kim, Hyangkyoug; Cho, Sungsin; Lee, Kwangjin; Lee, Seung Hwan; Joh, Jin Hyun
- Ewha Authors
- 김향경
- SCOPUS Author ID
- 김향경
- Issue Date
- 2023
- Journal Title
- ANNALS OF SURGICAL TREATMENT AND RESEARCH
- ISSN
- 2288-6575
2288-6796
- Citation
- ANNALS OF SURGICAL TREATMENT AND RESEARCH vol. 104, no. 5, pp. 288 - 295
- Keywords
- Chronic disease; Compliance; Drug-related side effects and adverse reactions; Veins; Venoactive drug
- Publisher
- KOREAN SURGICAL SOCIETY
- Indexed
- SCIE; SCOPUS; KCI
- Document Type
- Article
- Abstract
- Purpose: Venoactive drugs are widely used to improve the symptoms and signs of chronic venous disease. This study aimed to analyze the rate of adverse events after venoactive drug prescription and subsequent compliance and switching rates. Methods: Using the National Health Insurance Service database, individuals with at least one chronic venous disease code between January 2009 and December 2019 were identified, and 30% (2,216,780 individuals) of these were sampled. Finally, 1,551,212 patients were included, and we analyzed adverse events, compliance, and switching rates with 8 venoactive drugs, including Vitis vinifera extract, naftazone, micronized purified flavonoid fraction, Vitis vinifera leaf extract, diosmin, diobsilate calcium, bilberry fruit dried extract, and sulodexide. Results: The most commonly prescribed venoactive drug was Vitis vinifera extract (72.2%), followed by sulodexide (9.3%), and Vitis vinifera leaf dry extract (8.2%). Adverse event rates were significantly lower in the naftazone and diosmin groups (P = 0.001 and P = 0.002, respectively) and significantly higher in the Vitis vinifera leaf dry extract group (P = 0.009). Drug adherence to sulodexide was the highest throughout the study period, followed by billberry extract and dobesilate (all P < 0.001). For most drugs, the drug switching rate was low (<5.0%). Conclusion: Vitis vinifera extract was the most commonly prescribed venoactive drug in Korea, and drug adherence to sulodexide was the highest among all venoactive drugs. The adverse event rates were significantly lower in the naftazone and diosmin groups. [Ann Surg Treat Res 2023;104(5):288-295]
- DOI
- 10.4174/astr.2023.104.5.288|http://dx.doi.org/10.4174/astr.2023.104.5.288
- Appears in Collections:
- 의료원 > 의료원 > Journal papers
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