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The role of diuretic hormones (DHs) and their receptors in Drosophila
- Title
- The role of diuretic hormones (DHs) and their receptors in Drosophila
- Authors
- Lee, Gahbien; Fang, Heejin; Oh, Yangkyun
- Ewha Authors
- 오양균
- SCOPUS Author ID
- 오양균
- Issue Date
- 2023
- Journal Title
- BMB REPORTS
- ISSN
- 1976-6696
1976-670X
- Citation
- BMB REPORTS vol. 56, no. 4, pp. 209 - 215
- Keywords
- DH31; DH31 receptor; DH44; DH44 receptors; Drosophila; Feeding; Fluid secretion; Nutrient sensing; Sleep; wake cycle
- Publisher
- KOREAN SOCIETY BIOCHEMISTRY &
MOLECULAR BIOLOGY
- Indexed
- SCIE; SCOPUS; KCI
- Document Type
- Article
- Abstract
- Maintaining internal homeostasis and regulating innate behaviors are essential for animal survival. In various animal species, a highly conserved neuroendocrine system integrates sensory in-puts and regulates physiological responses to environmental and internal changes. Diuretic hormones 44 and 31, which are homo-logs of mammalian corticotropin-releasing factor (CRF) and cal-citonin gene-related peptide (CGRP), respectively, control body fluid secretion in Drosophila. These neuropeptides and their re-ceptors have multiple physiological roles, including the regula-tion of body-fluid secretion, sleep:wake cycle, internal nutrient -sensing, and CO2-dependent response. This review discusses the physiological and behavioral roles of DH44 and DH31 signaling pathways, consisting of neuroendocrine cells that secrete DH44 or DH31 peptides and their receptor-expressing organs. Further research is needed to understand the regulatory mechanisms of the behavioral processes mediated by these neuro-endocrine systems. [BMB Reports 2023; 56(4): 209-215]
- DOI
- 10.5483/BMBRep.2023-0021|http://dx.doi.org/10.5483/BMBRep.2023-0021
- Appears in Collections:
- 자연과학대학 > 생명과학전공 > Journal papers
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