Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 박영미 | * |
dc.contributor.author | 최장환 | * |
dc.date.accessioned | 2023-08-03T16:31:01Z | - |
dc.date.available | 2023-08-03T16:31:01Z | - |
dc.date.issued | 2023 | * |
dc.identifier.issn | 2376-5992 | * |
dc.identifier.other | OAK-33547 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/265460 | - |
dc.description.abstract | Predicting recurrence in patients with non-small cell lung cancer (NSCLC) before treatment is vital for guiding personalized medicine. Deep learning techniques have revolutionized the application of cancer informatics, including lung cancer timeto-event prediction. Most existing convolutional neural network (CNN) models are based on a single two-dimensional (2D) computational tomography (CT) image or three-dimensional (3D) CT volume. However, studies have shown that using multiscale input and fusing multiple networks provide promising performance. This study proposes a deep learning-based ensemble network for recurrence prediction using a dataset of 530 patients with NSCLC. This network assembles 2D CNN models of various input slices, scales, and convolutional kernels, using a deep learning-based feature fusion model as an ensemble strategy. The proposed framework is uniquely designed to benefit from (i) multiple 2D in-plane slices to provide more information than a single central slice, (ii) multi-scale networks and multi-kernel networks to capture the local and peritumoral features, (iii) ensemble design to integrate features from various inputs and model architectures for final prediction. The ensemble of five 2D-CNN models, three slices, and two multi-kernel networks, using 5 x 5 and 6 x 6 convolutional kernels, achieved the best performance with an accuracy of 69.62%, area under the curve (AUC) of 72.5%, F1 score of 70.12%, and recall of 70.81%. Furthermore, the proposed method achieved competitive results compared with the 2D and 3D-CNN models for cancer outcome prediction in the benchmark studies. Our model is also a potential adjuvant treatment tool for identifying NSCLC patients with a high risk of recurrence. | * |
dc.language | English | * |
dc.publisher | PEERJ INC | * |
dc.subject | Multi-scale network | * |
dc.subject | Multi-kernel network | * |
dc.subject | Ensemble model | * |
dc.subject | Non-small cell lung cancer | * |
dc.subject | Lung cancer recurrence | * |
dc.subject | Artificial neural network | * |
dc.subject | Deep learning | * |
dc.title | A multi-kernel and multi-scale learning based deep ensemble model for predicting recurrence of non-small cell lung cancer | * |
dc.type | Article | * |
dc.relation.volume | 9 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | PEERJ COMPUTER SCIENCE | * |
dc.identifier.doi | 10.7717/peerj-cs.1311|http://dx.doi.org/10.7717/peerj-cs.1311 | * |
dc.identifier.wosid | WOS:000996303500002 | * |
dc.author.google | Kim, Gihyeon | * |
dc.author.google | Park, Young Mi | * |
dc.author.google | Yoon, Hyun Jung | * |
dc.author.google | Choi, Jang-Hwan | * |
dc.contributor.scopusid | 박영미(7405372677) | * |
dc.contributor.scopusid | 최장환(55850525400) | * |
dc.date.modifydate | 20240318171633 | * |