Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 송태진 | * |
dc.contributor.author | 김형준 | * |
dc.date.accessioned | 2023-07-27T16:31:12Z | - |
dc.date.available | 2023-07-27T16:31:12Z | - |
dc.date.issued | 2023 | * |
dc.identifier.issn | 2405-8440 | * |
dc.identifier.other | OAK-33750 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/265160 | - |
dc.description.abstract | Objective: Famotidine has been proposed as a promising candidate for the treatment of corona-virus disease 2019 (COVID-19). However, there is limited research on the association of famo-tidine with the poor prognosis of COVID-19.Methods: The Korean nationwide cohort included 6,556 patients who tested positive on RT-PCR for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The poor COVID-19-related outcomes were defined on the basis of having encountered the composite outcome of high oxy-gen therapy, intensive care unit admission, administration of mechanical ventilation, or death. In addition, we performed exposure-driven propensity score matching for no H2-blocker use versus current famotidine use, and other H2-blocker use versus current famotidine use.Results: 4,785 (73.0%) patients did not use a H2-blocker, 393 (6.0%) patients were currently used famotidine, and 1,292 (19.7%) patients currently used H2-blocker other than famotidine. In multivariable analysis after matching (no H2-blocker use versus current famotidine use), there was no significant association between current famotidine use and composite outcomes (adjusted odd ratios [aOR]: 1.30, 95% confidence interval [CI]: 0.55-3.06). On the other hand, another matched cohort (other H2-blocker use versus current famotidine use), demonstrated a positive association between current famotidine use and composite outcomes (aOR: 3.56, 95% CI: 1.03-12.28) | * |
dc.language | English | * |
dc.publisher | CELL PRESS | * |
dc.subject | COVID-19 | * |
dc.subject | Famotidine | * |
dc.subject | Intensive care unit | * |
dc.subject | Mechanical ventilation | * |
dc.subject | Mortality | * |
dc.title | Effectiveness of famotidine on the risk of poor prognosis in patients with COVID-19: A nationwide cohort study in Korea | * |
dc.type | Article | * |
dc.relation.issue | 6 | * |
dc.relation.volume | 9 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | HELIYON | * |
dc.identifier.doi | 10.1016/j.heliyon.2023.e16171 | * |
dc.identifier.wosid | WOS:001043430500001 | * |
dc.identifier.scopusid | 2-s2.0-85161352546 | * |
dc.author.google | Kwon, Rosie | * |
dc.author.google | Kim, Hyung Jun | * |
dc.author.google | Lee, Seung Won | * |
dc.author.google | Koyanagi, Ai | * |
dc.author.google | Il Shin, Jae | * |
dc.author.google | Song, Tae-Jin | * |
dc.author.google | Yon, Dong Keon | * |
dc.author.google | Smith, Lee | * |
dc.contributor.scopusid | 송태진(55507164200) | * |
dc.contributor.scopusid | 김형준(57329146300;55635231700) | * |
dc.date.modifydate | 20240304123954 | * |