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Seeing the cis-Dihydroxylating Intermediate: A Mononuclear Nonheme Iron-Peroxo Complex in cis-Dihydroxylation Reactions Modeling Rieske Dioxygenases
- Title
- Seeing the cis-Dihydroxylating Intermediate: A Mononuclear Nonheme Iron-Peroxo Complex in cis-Dihydroxylation Reactions Modeling Rieske Dioxygenases
- Authors
- Zhu, Wenjuan; Kumar, Akhilesh; Xiong, Jin; Abernathy, Macon J.; Li, Xiao-Xi; Seo, Mi Sook; Lee, Yong-Min; Sarangi, Ritimukta; Guo, Yisong; Nam, Wonwoo
- Ewha Authors
- 남원우; 이용민; 서미숙; Li Xiao Xi; Akhilesh Kumar
- SCOPUS Author ID
- 남원우; 이용민; 서미숙; Li Xiao Xi; Akhilesh Kumar
- Issue Date
- 2023
- Journal Title
- JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- ISSN
- 0002-7863
1520-5126
- Citation
- JOURNAL OF THE AMERICAN CHEMICAL SOCIETY vol. 145, no. 8, pp. 4389 - 4393
- Publisher
- AMER CHEMICAL SOC
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- The nature of reactive intermediates and the mechanism of the cis-dihydroxylation of arenes and olefins by Rieske dioxygenases and synthetic nonheme iron catalysts have been the topic of intense research over the past several decades. In this study, we report that a spectroscopically well characterized mononuclear nonheme iron(III)-peroxo complex reacts with olefins and naphthalene derivatives, yielding iron(III) cycloadducts that are isolated and characterized structurally and spectroscopically. Kinetics and product analysis reveal that the nonheme iron(III)-peroxo complex is a nucleophile that reacts with olefins and naphthalenes to yield cis-diol products. The present study reports the first example of the cis-dihydroxylation of substrates by a nonheme iron(III)-peroxo complex that yields cis-diol products.
- DOI
- 10.1021/jacs.2c13551
- Appears in Collections:
- 자연과학대학 > 화학·나노과학전공 > Journal papers
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