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Comparison of outcomes of chronic kidney disease based on etiology: a prospective cohort study from KNOW-CKD
- Title
- Comparison of outcomes of chronic kidney disease based on etiology: a prospective cohort study from KNOW-CKD
- Authors
- Ryu; Hyunjin; Hong; Yeji; Kang; Eunjeong; Minjung; Kim; Jayoun; Park; Hayne Cho; Oh; Yun Kyu; Chin; Ho Jun; Sue K.; Jung; Ji Yong; Hyun; Young Youl; Sung; Su Ah; Ahn; Curie; Kook-Hwan; Lee; Hajeong; Han; Seung Seok; Ko; Youngok; So; Jeongok; Aram; Chae; Dong Wan; Yi; Yong Jin; Cho; Hyun Jin; Jung Eun; Choi; Kyu Hun; Seung Hyeok; Yoo; Tae-Hyun; Yu; Mi Hyun; Kyu-Beck; Hyun Jung; Yong-Soo; Sol Ji; Chung; Wookyung; Jin; Kwon Eun; Sung Woo; Min; Hyang Ki; Kwon; Soon Bin; Soo Wan; Ma; Seong Kwon; Bae; Eun Hui; Chang Seong; Hong Sang; Minah; Tae Ryom; Suh; Sang Heon; Song; Su Hyun; Se Jeong; Yeong Hoon; Sun Woo; Koo; Hoseok; Tae Hee; Yun Mi; Young Eun; Seong; Eun Young; Miyeun; Hyo Jin; Ji; Seunghee; Chang; Tae Ik; Ea Wha; Kyoung Sook; Aei Kyung; Ja-Ryong; Seo; Jang-Won; Sun Ryoung; Baek; Seon Ha; Myung Sun; Jeong Mi; Byung-Joo; Joongyub; Choonghyun; Kyungsik; Nam; Dayeon; Soohee; Juhee; Heejung; Dong Hee; Soyoung; Biobank; Korea; Ok; Il Yoel; Sung Hyun; Kyoung Hwa
- Ewha Authors
- 강은정
- SCOPUS Author ID
- 강은정
- Issue Date
- 2023
- Journal Title
- Scientific Reports
- ISSN
- 2045-2322
- Citation
- Scientific Reports vol. 13, no. 1
- Publisher
- Nature Research
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- The causes of chronic kidney disease (CKD) affects its outcomes. However, the relative risks for adverse outcomes according to specific causes of CKD is not well established. In a prospective cohort study from KNOW-CKD, a cohort was analyzed using overlap propensity score weighting methods. Patients were grouped into four categories according to the cause of CKD: glomerulonephritis (GN), diabetic nephropathy (DN), hypertensive nephropathy (HTN), or polycystic kidney disease (PKD). From a total of 2070 patients, the hazard ratio of kidney failure, the composite of cardiovascular disease (CVD) and mortality, and the slope of the estimated glomerular filtration rate (eGFR) decline according to the cause of CKD were compared between causative groups in a pairwise manner. There were 565 cases of kidney failure and 259 cases of composite CVD and death over 6.0 years of follow-up. Patients with PKD had a significantly increased risk for kidney failure compared to those with GN [Hazard ratio (HR) 1.82], HTN (HR 2.23), and DN (HR 1.73). For the composite outcome of CVD and death, the DN group had increased risks compared to the GN (HR 2.07), and HTN (HR 1.73) groups but not to the PKD group. The adjusted annual eGFR change for the DN and PKD groups were − 3.07 and − 3.37 mL/min/1.73 m2 per year, respectively, and all of these values were significantly different than those of the GN and HTN groups (− 2.16 and − 1.42 mL/min/1.73 m2 per year, respectively). In summary, the risk of kidney disease progression was relatively higher in patients with PKD compared to other causes of CKD. However, the composite of CVD and death was relatively higher in patients with DN-related CKD than in those with GN- and HTN-related CKD. © 2023, The Author(s).
- DOI
- 10.1038/s41598-023-29844-x
- Appears in Collections:
- 의료원 > 의료원 > Journal papers
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