NL repository
menu
검색
Library
Browse
Communities & Collections
By Date
Authors
Titles
Subject
My Repository
My Account
Receive email updates
Edit Profile
DSpace at EWHA
자연과학대학
화학·나노과학전공
Journal papers
View : 404 Download: 131
A novel splicing variant of DJ-1 in Parkinson's disease induces mitochondrial dysfunction
Title
A novel splicing variant of DJ-1 in Parkinson's disease induces mitochondrial dysfunction
Authors
Cho N.
;
Joo J.
;
Choi S.
;
Kang B.-G.
;
Lee A.J.
;
Youn S.-Y.
;
Park S.-H.
;
Kim E.-M.
;
Masliah E.
;
Ko Y.
;
Cha S.-S.
;
Jung I.
;
Kim K.K.
Ewha Authors
차선신
SCOPUS Author ID
차선신
Issue Date
2023
Journal Title
Heliyon
ISSN
2405-8440
Citation
Heliyon vol. 9, no. 3
Keywords
Alternative splicing
;
DJ-1
;
Mitochondria
;
PARK7
;
Parkinson's disease
Publisher
Elsevier Ltd
Indexed
SCIE; SCOPUS
Document Type
Article
Abstract
Several studies have identified mutations in neuroprotective genes in a few cases of Parkinson's disease (PD); however, the role of alternative splicing changes in PD remains unelucidated. Based on the transcriptome analysis of substantia nigra (SN) tissues obtained from PD cases and age-matched healthy controls, we identified a novel alternative splicing variant of DJ-1, lacking exon 6 (DJ-1ΔE6), frequently detected in the SN of patients with PD. We found that the exon 6 skipping of DJ-1 induces mitochondrial dysfunction and impaired antioxidant capability. According to an in silico modeling study, the exon 6 skipping of DJ-1 disrupts the structural state suitable for the oxidation of the cysteine 106 residue that is a prerequisite for activating its neuroprotective roles. Our results suggest that change in DJ-1 alternative splicing may contribute to PD progression and provide an insight for studying PD etiology and its potential therapeutic targets. © 2023 The Authors
DOI
10.1016/j.heliyon.2023.e14039
Appears in Collections:
자연과학대학
>
화학·나노과학전공
>
Journal papers
Files in This Item:
1-s2.0-S240584402301246X-main.pdf
(7.2 MB)
Download
Export
RIS (EndNote)
XLS (Excel)
XML
Show full item record
Find@EWHA
트윗하기
BROWSE
Communities & Collections
By Date
Authors
Titles
Subject