View : 391 Download: 68
Tsaokoic Acid: A New Bicyclic Nonene from the Fruits of Amomum tsao-ko with Acetylcholinesterase Inhibitory Activity
- Title
- Tsaokoic Acid: A New Bicyclic Nonene from the Fruits of Amomum tsao-ko with Acetylcholinesterase Inhibitory Activity
- Authors
- Kim H.; Lee H.; Jung H.J.; Noh S.G.; Youn I.; Kwak H.; Lee Y.; Nam S.-J.; Kang S.; Chung H.Y.; Seo E.K.
- Ewha Authors
- 서은경; 남상집; 강수성
- SCOPUS Author ID
- 서은경; 남상집; 강수성
- Issue Date
- 2023
- Journal Title
- Molecules
- ISSN
- 1420-3049
- Citation
- Molecules vol. 28, no. 6
- Keywords
- acetylcholinesterase; Amomum tsao-ko; bicyclic nonene; Zingiberaceae
- Publisher
- MDPI
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- A new bicyclic nonene, tsaokoic acid (1), was isolated from the fruits of Amomum tsao-ko, together with three known compounds (2–4). The structure of 1 was elucidated by analyzing spectroscopic data including 1D and 2D NMR spectra and compounds 2–4 were identified as tsaokoin, vanillin, and tsaokoarylone, respectively, by comparing their NMR spectra with previously reported data. Compounds 1–4 showed possible inhibitory activity against acetylcholinesterase (AChE) in silico molecular docking simulations. They were submitted to in vitro assay system and exhibited moderate inhibitory activity with IC50 values of 32.78, 41.70, 39.25, and 31.13 μM, respectively. © 2023 by the authors.
- DOI
- 10.3390/molecules28062602
- Appears in Collections:
- 약학대학 > 약학과 > Journal papers
- Files in This Item:
-
molecules-28-02602.pdf(1.52 MB)
Download
- Export
- RIS (EndNote)
- XLS (Excel)
- XML