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Immunogenicity of SARS-CoV-2 Vaccine in Kidney Transplant Recipients: A Cross-Sectional Study in Korea

Title
Immunogenicity of SARS-CoV-2 Vaccine in Kidney Transplant Recipients: A Cross-Sectional Study in Korea
Authors
Song, Seung HwanChung, Ku YongJee, YonghoChung, Hae-SunKim, KinaMinn, DohsikKim, Soo-Kyung
Ewha Authors
정혜선송승환김수경
SCOPUS Author ID
정혜선scopus; 송승환scopus; 김수경scopusscopusscopus
Issue Date
2023
Journal Title
JOURNAL OF KOREAN MEDICAL SCIENCE
ISSN
1011-8934JCR Link

1598-6357JCR Link
Citation
JOURNAL OF KOREAN MEDICAL SCIENCE vol. 38, no. 5
Keywords
COVID-19Kidney TransplantationSARS-CoV-2Vaccine
Publisher
KOREAN ACAD MEDICAL SCIENCES
Indexed
SCIE; SCOPUS; KCI WOS scopus
Document Type
Article
Abstract
Eighty-five Korean kidney transplant recipients who received three doses of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine were tested with anti-receptor binding domain (RBD) antibody and neutralizing antibody. High anti-RBD antibody (>= 100 U/mL) and neutralizing antibody responses (>= 30%) were detected in 51/85 (60.0%) patients. When we divided the patients with the time from transplantation to vaccination (< 1, 1-2.4, 2.5-4.9, and >= 5-year), anti-RBD antibody titers were 3.2 U/mL, 27.8 U/mL, 370.2 U/mL, and 5,094.2 U/mL (P < 0.001) and anti-neutralizing antibody levels were 2.2%, 11.6%, 45.6%, and 93.0% (P < 0.001), respectively. Multivariate analysis revealed increased antibody responses when the time from transplantation to vaccination was five years or longer (odds ratio, 12.0; confidence interval, 2.7-52.8). Korean kidney transplant recipients had suboptimal antibody responses after the third dose of SARS-CoV-2 vaccine. A shorter time from transplantation to vaccination was a risk factor for a low antibody response.
DOI
10.3346/jkms.2023.38.e22
Appears in Collections:
의과대학 > 의학과 > Journal papers
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