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Brownian ratchet for directional nanoparticle transport by repetitive stretch-relaxation of DNA
- Title
- Brownian ratchet for directional nanoparticle transport by repetitive stretch-relaxation of DNA
- Authors
- Oh, Inrok; Song, Jeongeun; Hyun, Hye Ree; Lee, Sang Hak; Kim, Jun Soo
- Ewha Authors
- 김준수
- SCOPUS Author ID
- 김준수
- Issue Date
- 2022
- Journal Title
- PHYSICAL REVIEW E
- ISSN
- 2470-0045
2470-0053
- Citation
- PHYSICAL REVIEW E vol. 106, no. 5
- Publisher
- AMER PHYSICAL SOC
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Brownian motion subject to a periodic and asymmetric potential can be biased by external, nonequilibrium fluctuations, leading to directional movement of Brownian particles. Sequence-dependent flexibility variation along double-stranded DNA has been proposed as a tool to develop periodic and asymmetric potentials for DNA binding of cationic nanoparticles with sizes below tens of nanometers. Here, we propose that repetitive stretching and relaxation of a long, double-stranded DNA molecule with periodic flexibility gradient can induce nonequilibrium fluctuations that tune the amplitude of asymmetric potentials for DNA-nanoparticle binding to result in directional transport of nanometer-sized particles along DNA. Realization of the proposed Brownian ratchet was proven by Brownian dynamics simulations of coarse-grained models of a single, long DNA molecule with flexibility variation and a cationic nanoparticle.
- DOI
- 10.1103/PhysRevE.106.054117
- Appears in Collections:
- 자연과학대학 > 화학·나노과학전공 > Journal papers
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