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Comparison of amikacin with fosfomycin as an add-on to ciprofloxacin for antibiotic prophylaxis in transrectal prostate biopsy: A single-center retrospective study

Title
Comparison of amikacin with fosfomycin as an add-on to ciprofloxacin for antibiotic prophylaxis in transrectal prostate biopsy: A single-center retrospective study
Authors
Yu, Seong HyeonJung, Seung, IIRyu, Ji WonKim, Myung SooChung, Ho SeokHwang, Eu ChangKwon, Dong Deuk
Ewha Authors
김명수
SCOPUS Author ID
김명수scopus
Issue Date
2022
Journal Title
INVESTIGATIVE AND CLINICAL UROLOGY
ISSN
2466-0493JCR Link

2466-054XJCR Link
Citation
INVESTIGATIVE AND CLINICAL UROLOGY vol. 63, no. 6, pp. 663 - 670
Keywords
Antibiotic prophylaxisBiopsyCiprofloxacinFosfomycinProstate
Publisher
KOREAN UROLOGICAL ASSOC
Indexed
SCIE; SCOPUS; KCI WOS
Document Type
Article
Abstract
Purpose: To assess the effect of ciprofloxacin (CP) and fosfomycin compared with CP and amikacin in patients with a fluoroquino-lone (FQ)-resistant rectal flora who have undergone transrectal ultrasound-guided prostate biopsy (TRUSPB).Materials and Methods: In total, 516 patients with FQ-resistant rectal flora based on rectal swab cultures were divided into two groups according to prophylactic antibiotics. Patients in both groups were administered CP (400 mg, intravenous [IV], twice daily) on the same day as TRUSPB and 1 day after biopsy. The amikacin group (n=260) was administered a single injection of amikacin (1 g, IV) 1 hour before TRUSPB, whereas the fosfomycin group (n=256) was administered fosfomycin (3 g, orally) the night before the procedure. The primary endpoint was the rate of infectious complications in the two groups. Results: Overall, 13 patients (2.5%) reported infectious complications: 12 patients (4.62%) in the amikacin group compared with 1 patient (0.39%) in the fosfomycin group (risk ratio, 0.09; 95% confidence interval [CI], 0.01-0.65), respectively, which was a statisti-cally significant difference (p=0.017). This corresponds to a number needed to treat of 24 patients (95% CI, 15-65) to prevent one infectious complication. In the multivariate analysis to assess variables related to infectious complications, prophylactic antibiotics with added fosfomycin was associated with infectious complications (odds ratio, 0.060; 95% CI, 0.008-0.459).Conclusions: In the era of FQ resistance, CP and fosfomycin may reduce the rate of infectious complications compared with CP and amikacin prophylaxis.
DOI
10.4111/icu.20220147
Appears in Collections:
의료원 > 의료원 > Journal papers
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