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BRCA1 deficiency in triple-negative breast cancer: Protein stability as a basis for therapy
- Title
- BRCA1 deficiency in triple-negative breast cancer: Protein stability as a basis for therapy
- Authors
- Choi, Eun; Mun, Gil-im; Lee, Joohyun; Lee, Hanhee; Cho, Jaeho; Lee, Yun-Sil
- Ewha Authors
- 이윤실; 문길임
- SCOPUS Author ID
- 이윤실; 문길임
- Issue Date
- 2023
- Journal Title
- BIOMEDICINE & PHARMACOTHERAPY
- ISSN
- 0753-3322
1950-6007
- Citation
- BIOMEDICINE & PHARMACOTHERAPY vol. 158
- Keywords
- BRCA1 deficiency; Triple -negative breast cancer; Proteasomal degradation; Chemotherapy resistance; Multifunction
- Publisher
- ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
- Indexed
- SCIE; SCOPUS
- Document Type
- Review
- Abstract
- Mutations in breast cancer-associated 1 (BRCA1) increase the lifetime risk of developing breast cancer by up to 51% over the risk of the general population. Many aspects of this multifunctional protein have been revealed, including its essential role in homologous recombination repair, E3 ubiquitin ligase activity, transcriptional regulation, and apoptosis. Although most studies have focused on BRCA1 deficiency due to mutations, only a minority of patients carry BRCA1 mutations. A recent study has suggested an expanded definition of BRCA1 deficiency with reduced BRCA1 levels, which accounts for almost half of all triple-negative breast cancer (TNBC) patients. Reduced BRCA1 levels can result from epigenetic modifications or increased proteasomal degradation. In this review, we discuss how this knowledge of BRCA1 function and regulation of BRCA1 protein stability can help overcome the challenges encountered in the clinic and advance current treatment strategies for BRCA1related breast cancer patients, especially focusing on TNBC.
- DOI
- 10.1016/j.biopha.2022.114090
- Appears in Collections:
- 약학대학 > 약학과 > Journal papers
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