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Prospective evaluation of low-dose multiphase hepatic computed tomography for detecting and characterizing hepatocellular carcinoma in patients with chronic liver disease

Title
Prospective evaluation of low-dose multiphase hepatic computed tomography for detecting and characterizing hepatocellular carcinoma in patients with chronic liver disease
Authors
Choi, Eun SunKim, Jin SilLee, Jeong KyongLee, Hye AhPak, Seongyong
Ewha Authors
이정경김진실이혜아
SCOPUS Author ID
이정경scopus; 김진실scopus; 이혜아scopus
Issue Date
2022
Journal Title
BMC MEDICAL IMAGING
ISSN
1471-2342JCR Link
Citation
BMC MEDICAL IMAGING vol. 22, no. 1
Keywords
Multidetector computed tomographyRadiation doseHepatocellular carcinomaLow-dose CTUltralow-dose CT
Publisher
BMC
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Background: Knowing the lowest acceptable radiation dose of multiphase hepatic CT may allow us to reduce the radiation dose for detecting HCC.Purpose: To prospectively assess the image quality and diagnostic performance of low-dose and ultra-low-dose multiphase hepatic computed tomography using a dual-source CT scanner.Methods: Three reconstructed different dose scan images (standard-dose, low-dose, and ultra-low-dose) of hepatic multiphase CT were obtained from 67 patients with a dual-source CT scanner. The image quality and the diagnostic performance of the three radiation dose CT scans of the hepatic focal lesion (>= 0.5 cm) were analyzed by two inde-pendent readers using the Liver Imaging Reporting and Data System.Results: Qualitative image quality and signal-to-noise ratio were significantly different among the radiation doses (p < 0.001). In total, 154 lesions comprising 32 hepatocellular carcinomas (HCC) and 122 non-HCC were included. The sensitivities of SDCT, LDCT, and ULDCT were 90.6%(29/32), 81.3%(26/32), and 56.2%(18/32), respectively. The accura-cies of SDCT, LDCT, and ULDCT were 98.1%(151/154), 96.1%(148/154), and 89.6%(138/154), respectively. On per-lesion analysis, SDCT and LDCT did not show significantly different sensitivity and accuracy in diagnosing HCC (p = 0.250 and 0.250). Conclusions: The diagnostic performance of dynamic hepatic LDCT with 33% reduced radiation dose in comparison to SDCT would be acceptable even though its image quality was qualitatively and quantitatively inferior. However, few HCCs could be overlooked. Therefore, with caution, radiation dose reduction by one-third could be implemented for follow-up CT scans for patients suspected of having HCC with caution and further studies are needed in the future.
DOI
10.1186/s12880-022-00947-7
Appears in Collections:
의과대학 > 의학과 > Journal papers
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