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Association between A Family History of Colorectal Cancer and the Risk of Colorectal Cancer: A Nationwide Population-Based Study
- Title
- Association between A Family History of Colorectal Cancer and the Risk of Colorectal Cancer: A Nationwide Population-Based Study
- Authors
- Jung, Yoon Suk; Song, Huiyeon; Tran, Mai Thi Xuan; Park, Boyoung; Moon, Chang Mo
- Ewha Authors
- 문창모
- SCOPUS Author ID
- 문창모
- Issue Date
- 2022
- Journal Title
- JOURNAL OF PERSONALIZED MEDICINE
- ISSN
- 2075-4426
- Citation
- JOURNAL OF PERSONALIZED MEDICINE vol. 12, no. 10
- Keywords
- family history; colorectal cancer; age
- Publisher
- MDPI
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Large-scale Asian studies on this topic are lacking. We evaluated the CRC risk associated with family history in the Korean population. We analyzed the data of participants aged >= 40 years who underwent national cancer screening between 2013 and 2014. During a mean follow-up of 4.7 +/- 0.8 years, 0.43% of the 292,467 participants with family history and 0.28% of the 1,169,868 participants without family history developed CRC. Participants with a family history in any FDR, parents only, and siblings only had a higher risk of CRC than those without family history; adjusted hazard ratios (HRs) were 1.53, 1.46, and 1.61, respectively. Participants with a family history comprising both parents and siblings had an even higher risk of CRC than those without a family history (HR, 2.34). The HRs for CRC in the 40-49, 50-59, 60-69, 70-79, and >= 80 age groups with family history were 1.72, 1.74, 1.50, 1.30, and 0.78, respectively (p < 0.001). A family history of CRC in any FDR and both parents and siblings was associated with an approximately 1.5- and 2.3-fold increased risk of CRC. The effect of family history was relatively greater in the younger than the older age group.
- DOI
- 10.3390/jpm12101566
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
- Files in This Item:
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