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Changes in Etiology of Invasive Bacterial Infections in Infants under 3 Months of Age in Korea, 2006-2020
- Title
- Changes in Etiology of Invasive Bacterial Infections in Infants under 3 Months of Age in Korea, 2006-2020
- Authors
- Song S.H.; Lee H.J.; Song E.S.; Ahn J.G.; Park S.E.; Lee T.; Cho H.-K.; Lee J.; Kim Y.-J.; Jo D.S.; Kim J.-H.; Kang H.M.; Lee J.K.; Kim C.S.; Kim D.H.; Kim H.M.; Choi J.H.; Eun B.W.; Kim N.H.; Cho E.Y.; Kim Y.-K.; Oh C.E.; Kim K.-H.; Ma S.H.; Jung H.J.; Lee K.S.; Kim K.N.; Lee H.; Choi E.H.
- Ewha Authors
- 김경효
- SCOPUS Author ID
- 김경효
- Issue Date
- 2022
- Journal Title
- Pediatric Infectious Disease Journal
- ISSN
- 0891-3668
- Citation
- Pediatric Infectious Disease Journal vol. 41, no. 12, pp. 941 - 946
- Publisher
- Lippincott Williams and Wilkins
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Objectives: Invasive bacterial infection (IBI) causes a significant burden in infants. In this study, we analyzed changes in epidemiology of IBI among infants in Korea. Methods: A retrospective multicenter-based surveillance for IBIs in infants <3 months of age was performed during 2006-2020. Cases were classified as an early-onset disease (EOD) (0-6 days) or late-onset disease (LOD) (7-89 days). The temporal trend change in proportion of pathogens was analyzed. Results: Among 1545 cases, the median age was 28 days (IQR: 12, 53) and EOD accounted for 17.7%. Among pathogens, S. agalactiae (40.4%), E. coli (38.5%), and S. aureus (17.8%) were the most common and attributed for 96.7%. Among EOD (n = 274), S. agalactiae (45.6%), S. aureus (31.4%), E. coli (17.2%) and L. monocytogenes (2.9%) were most common. Among LOD (n = 1274), E. coli (43.1%), S. agalactiae (39.3%), S. aureus (14.9%) and S. pneumoniae (1.3%) were most common. In the trend analysis, the proportion of S. aureus (r s = -0.850, P < 0.01) decreased significantly, while that of S. agalactiae increased (r s = 0.781, P < 0.01). Conclusion: During 2006-2020, among IBI in infants <3 months of age, S. agalactiae, E. coli, and S. aureus were most common and an increasing trend of S. agalactiae was observed. © 2022 Lippincott Williams and Wilkins. All rights reserved.
- DOI
- 10.1097/INF.0000000000003714
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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