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Outcome in Patients Treated with Intra-arterial thrombectomy: The optiMAL Blood Pressure control (OPTIMAL-BP) Trial

Title
Outcome in Patients Treated with Intra-arterial thrombectomy: The optiMAL Blood Pressure control (OPTIMAL-BP) Trial
Authors
Nam H.S.Kim Y.D.Choi J.K.Baik M.Kim B.M.Kim D.J.Heo J.Shin D.H.Lee K.-Y.Jung Y.H.Baek J.-H.Hwang Y.-H.Sohn S.-I.Hong J.-H.Park H.Kim C.K.Kim G.S.Seo K.-D.Lee K.Seo J.H.Bang O.Y.Seo W.-K.Chung J.-W.Chang J.Y.Kwon S.U.Lee J.Kim J.Yoo J.Song T.-J.Ahn S.H.Cho B.-H.Cho H.-J.Kim J.G.Chang Y.Lee C.J.Park S.Park G.Lee H.S.
Ewha Authors
송태진장윤경
SCOPUS Author ID
송태진scopusscopus; 장윤경scopus
Issue Date
2022
Journal Title
International Journal of Stroke
ISSN
1747-4930JCR Link
Citation
International Journal of Stroke vol. 17, no. 8, pp. 931 - 937
Keywords
blood pressurecerebral infarctionoutcome researchReperfusion therapy
Publisher
SAGE Publications Inc.
Indexed
SCIE; SCOPUS scopus
Document Type
Article
Abstract
Rationale: Very early stage blood pressure (BP) levels may affect outcome in stroke patients who have successfully undergone recanalization following intra-arterial treatment, but the optimal target of BP management remains uncertain. Aim: We hypothesized that the clinical outcome after intensive BP-lowering is superior to conventional BP control after successful recanalization by intra-arterial treatment. Sample-size estimates: We aim to randomize 668 patients (334 per arm), 1:1. Methods and design: We initiated a multicenter, prospective, randomized, open-label trial with a blinded end-point assessment (PROBE) design. After successful recanalization (thrombolysis in cerebral infarction score ≥ 2 b), patients with elevated systolic BP level, defined as the mean of two readings ≥ 140 mmHg, will be randomly assigned to the intensive BP-lowering (systolic BP < 140 mm Hg) group or the conventional BP-lowering (systolic BP, 140−180 mm Hg) group. Study outcomes: The primary efficacy outcomes are from dichotomized analysis of modified Rankin Scale (mRS) scores at three months (mRS scores: 0–2 vs. 3–6). The primary safety outcomes are symptomatic intracerebral hemorrhage and death within three months. Discussion: The OPTIMAL-BP trial will provide evidence for the effectiveness of active BP control to achieve systolic BP < 140 mmHg during 24 h in patients with successful recanalization after intra-arterial treatment. Clinical trial registration: ClinicalTrials.gov Identifier: NCT04205305. © 2021 World Stroke Organization.
DOI
10.1177/17474930211041213
Appears in Collections:
의과대학 > 의학과 > Journal papers
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