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Targeted Discovery of an Enediyne-Derived Cycloaromatized Compound, Jejucarboside A, from a Marine Actinomycete
- Title
- Targeted Discovery of an Enediyne-Derived Cycloaromatized Compound, Jejucarboside A, from a Marine Actinomycete
- Authors
- Im J.H.; Shin D.; Ban Y.H.; Byun W.S.; Bae E.S.; Lee D.; Du Y.E.; Cui J.; Kwon Y.; Nam S.-J.; Cha S.; Lee S.K.; Yoon Y.J.; Oh D.-C.
- Ewha Authors
- 남상집
- SCOPUS Author ID
- 남상집
- Issue Date
- 2022
- Journal Title
- Organic Letters
- ISSN
- 1523-7060
- Citation
- Organic Letters vol. 24, no. 39, pp. 7188 - 7193
- Publisher
- American Chemical Society
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- A genomic and spectroscopic signature-based search revealed a cycloaromatized enediyne, jejucarboside A (1), from a marine actinomycete strain. The structure of 1 was determined as a new cyclopenta[a]indene glycoside bearing carbonate functionality by nuclear magnetic resonance, high-resolution mass spectrometry (MS), MS/MS, infrared spectroscopy, and a modified Mosher's method. An iterative enediyne synthase pathway has been proposed for the putative biosynthesis of 1 by genomic analysis. Jejucarboside A exhibited cytotoxicity against the HCT116 colon carcinoma cells. © 2022 American Chemical Society. All rights reserved.
- DOI
- 10.1021/acs.orglett.2c02934
- Appears in Collections:
- 자연과학대학 > 화학·나노과학전공 > Journal papers
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