Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 권영주 | * |
dc.date.accessioned | 2022-10-27T16:31:39Z | - |
dc.date.available | 2022-10-27T16:31:39Z | - |
dc.date.issued | 2022 | * |
dc.identifier.issn | 1011-8934 | * |
dc.identifier.issn | 1598-6357 | * |
dc.identifier.other | OAK-32230 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/262779 | - |
dc.description.abstract | Background: Benzo(a)pyrene (BaP) is a carcinogenic compound in contaminated foodstuffs. The effect of oral intake of the environmental carcinogen BaP under low doses and frequent exposure on a digestive system has not been thoroughly verified. Methods: In this regard, this study was conducted to prove the toxicity effects of BaP on the stomach and colon tissue after exposure to C57BL/6 mouse (3 and 6 jig/kg) following daily oral administration for 60 days. This study investigated acute gastric mucosal injury, severe gastric edema, cell infiltration, and mononuclear cells, multifocal cells, and tumoral inflammatory cells. Results: The results of ELISA showed that the expression of serum interleukin (IL)-6 and tumor necrosis factor-alpha in the BaP exposure group were significantly increased, and a high level of DNA adduct distribution in their stomach and colon. Moreover, this study has confirmed the expression of early carcinogenesis markers: nuclear factor (NF)-Kappa B, p53, IL-6, superoxide dismutase 1 (SOD1), mucin (MUC1 and MUC2), and beta-catenin in the stomach and colon, and showed that there was a significant increase in IL-6, NF-Kappa B, SOD1, beta-catenin, and MUC1 (P < 0.05). At the same time, there was a significant decrease in MUC2 and p53 (P < 0.05). Thus, even in low doses, oral intake of BaP can induce DNA damage, increasing the potential risk of gastrointestinal cancer. Conclusion: This study will provide a scientific basis for researching environmental contaminated food and intestinal health following daily oral administration of BaP. | * |
dc.language | English | * |
dc.publisher | KOREAN ACAD MEDICAL SCIENCES | * |
dc.subject | Benzo(a)pyrene | * |
dc.subject | Gastrointestinal Cancer | * |
dc.subject | Oral Intake | * |
dc.subject | Low -Dose | * |
dc.subject | p53 | * |
dc.subject | MUC | * |
dc.title | The Risk of Gastrointestinal Cancer on Daily Intake of Low-Dose BaP in C57BL/6 for 60 Days | * |
dc.type | Article | * |
dc.relation.issue | 30 | * |
dc.relation.volume | 37 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.index | KCI | * |
dc.relation.journaltitle | JOURNAL OF KOREAN MEDICAL SCIENCE | * |
dc.identifier.doi | 10.3346/jkms.2022.37.e235 | * |
dc.identifier.wosid | WOS:000835330500003 | * |
dc.author.google | Zheng, Zhi | * |
dc.author.google | Park, Jung Kuk | * |
dc.author.google | Kwon, Oh Wook | * |
dc.author.google | Ahn, Sung Hoon | * |
dc.author.google | Kwon, Young Joo | * |
dc.author.google | Jiang, Linjuan | * |
dc.author.google | Zhu, Shaohui | * |
dc.author.google | Park, Byoung Hee | * |
dc.contributor.scopusid | 권영주(12446435600) | * |
dc.date.modifydate | 20240422124907 | * |