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The Risk of Gastrointestinal Cancer on Daily Intake of Low-Dose BaP in C57BL/6 for 60 Days
- Title
- The Risk of Gastrointestinal Cancer on Daily Intake of Low-Dose BaP in C57BL/6 for 60 Days
- Authors
- Zheng, Zhi; Park, Jung Kuk; Kwon, Oh Wook; Ahn, Sung Hoon; Kwon, Young Joo; Jiang, Linjuan; Zhu, Shaohui; Park, Byoung Hee
- Ewha Authors
- 권영주
- SCOPUS Author ID
- 권영주
- Issue Date
- 2022
- Journal Title
- JOURNAL OF KOREAN MEDICAL SCIENCE
- ISSN
- 1011-8934
1598-6357
- Citation
- JOURNAL OF KOREAN MEDICAL SCIENCE vol. 37, no. 30
- Keywords
- Benzo(a)pyrene; Gastrointestinal Cancer; Oral Intake; Low -Dose; p53; MUC
- Publisher
- KOREAN ACAD MEDICAL SCIENCES
- Indexed
- SCIE; SCOPUS; KCI
- Document Type
- Article
- Abstract
- Background: Benzo(a)pyrene (BaP) is a carcinogenic compound in contaminated foodstuffs. The effect of oral intake of the environmental carcinogen BaP under low doses and frequent exposure on a digestive system has not been thoroughly verified. Methods: In this regard, this study was conducted to prove the toxicity effects of BaP on the stomach and colon tissue after exposure to C57BL/6 mouse (3 and 6 jig/kg) following daily oral administration for 60 days. This study investigated acute gastric mucosal injury, severe gastric edema, cell infiltration, and mononuclear cells, multifocal cells, and tumoral inflammatory cells. Results: The results of ELISA showed that the expression of serum interleukin (IL)-6 and tumor necrosis factor-alpha in the BaP exposure group were significantly increased, and a high level of DNA adduct distribution in their stomach and colon. Moreover, this study has confirmed the expression of early carcinogenesis markers: nuclear factor (NF)-Kappa B, p53, IL-6, superoxide dismutase 1 (SOD1), mucin (MUC1 and MUC2), and beta-catenin in the stomach and colon, and showed that there was a significant increase in IL-6, NF-Kappa B, SOD1, beta-catenin, and MUC1 (P < 0.05). At the same time, there was a significant decrease in MUC2 and p53 (P < 0.05). Thus, even in low doses, oral intake of BaP can induce DNA damage, increasing the potential risk of gastrointestinal cancer. Conclusion: This study will provide a scientific basis for researching environmental contaminated food and intestinal health following daily oral administration of BaP.
- DOI
- 10.3346/jkms.2022.37.e235
- Appears in Collections:
- 약학대학 > 약학과 > Journal papers
- Files in This Item:
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