Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 사홍기 | - |
dc.date.accessioned | 2022-10-27T16:31:26Z | - |
dc.date.available | 2022-10-27T16:31:26Z | - |
dc.date.issued | 2022 | - |
dc.identifier.issn | 1999-4923 | - |
dc.identifier.other | OAK-32282 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/262731 | - |
dc.description.abstract | Currently, emulsification-templated nanoencapsulation techniques (e.g., nanoprecipitation) have been most frequently used to prepare poly-d,l-lactide-co-glycolide (PLGA) nanoparticles. This study aimed to explore a new top-down process to produce PLGA nanoparticles. The fundamental strategy was to prepare spongelike PLGA microspheres with a highly porous texture and then crush them into submicron-sized particles via wet milling. Therefore, an ethyl formate-based ammonolysis method was developed to encapsulate progesterone into porous PLGA microspheres. Compared to a conventional solvent evaporation process, the ammonolysis technique helped reduce the tendency of drug crystallization and improved drug encapsulation efficiency accordingly (solvent evaporation, 27.6 +/- 4.6%; ammonolysis, 65.1 +/- 1.7%). Wet milling was performed on the highly porous microspheres with a D-50 of 64.8 mu m under various milling conditions. The size of the grinding medium was the most crucial factor for our wet milling. Milling using smaller zirconium oxide beads (0.3 similar to 1 mm) was simply ineffective. However, when larger beads with diameters of 3 and 5 mm were used, our porous microspheres were ground into submicron-sized particles. The quality of the resultant PLGA nanoparticles was demonstrated by size distribution measurement and field emission scanning electron microscopy. The present top-down process that contrasts with conventional bottom-up approaches might find application in manufacturing drug-loaded PLGA nanoparticles. | - |
dc.language | English | - |
dc.publisher | MDPI | - |
dc.subject | poly-d,l-lactide-co-glycolide | - |
dc.subject | microspheres | - |
dc.subject | nanoparticles | - |
dc.subject | wet milling | - |
dc.title | Preparation of PLGA Nanoparticles by Milling Spongelike PLGA Microspheres | - |
dc.type | Article | - |
dc.relation.issue | 8 | - |
dc.relation.volume | 14 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.journaltitle | PHARMACEUTICS | - |
dc.identifier.doi | 10.3390/pharmaceutics14081540 | - |
dc.identifier.wosid | WOS:000845793900001 | - |
dc.author.google | Lee, Jimin | - |
dc.author.google | Sah, Hongkee | - |
dc.contributor.scopusid | 사홍기(56127728100) | - |
dc.date.modifydate | 20221229151054 | - |