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5G Electromagnetic Radiation Attenuates Skin Melanogenesis In Vitro by Suppressing ROS Generation
- Title
- 5G Electromagnetic Radiation Attenuates Skin Melanogenesis In Vitro by Suppressing ROS Generation
- Authors
- Kim, Kyuri; Lee, Young Seung; Kim, Nam; Choi, Hyung-Do; Lim, Kyung-Min
- Ewha Authors
- 임경민
- SCOPUS Author ID
- 임경민
- Issue Date
- 2022
- Journal Title
- ANTIOXIDANTS
- ISSN
- 2076-3921
- Citation
- ANTIOXIDANTS vol. 11, no. 8
- Keywords
- non-ionizing radiation; electromagnetic waves; 5G; skin pigmentation; melanogenesis
- Publisher
- MDPI
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Recently, the impacts of 5G electromagnetic radiation (EMR) with 28 GHz on human health have been attracting public attention with the advent of 5G wireless communication. Here, we report that 5G (28 GHz) EMR can attenuate the skin pigmentation in murine melanoma cells (B16F10) and a 3D pigmented human epidermis model (Melanoderm (TM)). B16 cells were exposed to 5G (28 GHz) with or without alpha-MSH for 4 h per day. Interestingly, 5G attenuated alpha-MSH-induced melanin synthesis. Fontana-Masson staining confirmed that the dendritic formation of alpha-MSH stimulated B16 cells was diminished by 5G exposure. To confirm the anti-melanogenic effect of 5G EMR, MelanoDerm (TM) was irradiated with 5G at a power intensity of 10 W/m(2) for 4 h a day for 16 days and melanin distribution was detected with Fontana-Masson staining, which supported the anti-melanogenic effect of 5G EMR. Consistently, 5G EMR suppressed alpha-MSH induced upregulation of melanogenic enzymes; tyrosinase, TRP-1, and TRP-2. Of note, 5G EMR attenuated ROS production stimulated by alpha-MSH and H2O2, suggesting that 5G EMR may dissipate ROS generation, which is pivotal for the melanin synthesis. Collectively, we demonstrated that 5G EMR can attenuate skin pigmentation by attenuating ROS generation.
- DOI
- 10.3390/antiox11081449
- Appears in Collections:
- 약학대학 > 약학과 > Journal papers
- Files in This Item:
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antioxidants-11-01449.pdf(4.38 MB)
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